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Ms4a1 Antibody

  • 货号：
    CSB-PA015007LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Ms4a1 antibody at 4µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: Jurkat whole cell lysate
      Lane 3: 293T whole cell lysate
      Lane 4: HL60 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 32 kDa
      Observed band size: 32 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Ms4a1 Polyclonal antibody
  • Uniprot No.：
    P19437
  • 基因名：
  • 别名：
    Ms4a1 antibody; Cd20 antibody; Ly-44 antibody; Ms4a2 antibody; B-lymphocyte antigen CD20 antibody; B-cell differentiation antigen Ly-44 antibody; Lymphocyte antigen 44 antibody; Membrane-spanning 4-domains subfamily A member 1 antibody; CD antigen CD20 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse, Human
  • 免疫原：
    Recombinant Mouse B-lymphocyte antigen CD20 protein (111-291AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Ms4a1 Antibody (CSB-PA015007LA01MO)，的标记方式是Non-conjugated。对于Ms4a1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015007LB01MO Ms4a1 Antibody, HRP conjugated ELISA
    FITC CSB-PA015007LC01MO Ms4a1 Antibody, FITC conjugated
    Biotin CSB-PA015007LD01MO Ms4a1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.
  • 基因功能参考文献：
    1. Our findings indicate that anti-CD20-IFNalpha eradicates B-cell lymphoma by employing tumor cells as antigen-presenting cells to reactivate tumor-infiltrating CD8(+) T cells and synergizing with anti-PD-L1 treatment PMID: 28533311
    2. Galectin-1 has a role in driving lymphoma CD20 immunotherapy resistance in a mouse model PMID: 26888257
    3. Results indicate that an antigen-specific B cell response towards intracellular pathogens can be generated during anti-CD20 depletion therapy. PMID: 26261496
    4. this study demonstrates a role for CD20 in B cell activation and T-dependent humoral immunity. PMID: 23966626
    5. CD20 is required for store-operated calcium entry in C2C12 myoblasts. PMID: 22982241
    6. immunization of mice with the CD20 extracellular domain-6 using Freund's or QS-21 adjuvants was shown to exert significant biological effects in vivo with the pronounced depletion of splenic B cells. PMID: 20189250
    7. type I CD20 antibody cytotoxicity critically depends on Fc receptor ITAM signaling PMID: 20354182
    8. CD20 deficiency in humans results in impaired T cell-independent antibody responses. PMID: 20038800
    9. review of structure, function, tissue and cell distribution PMID: 12144126
    10. Anti-CD20 antibodies rapidly depleted the vast majority of circulating and tissue B cells in an isotype-restricted manner dependent on effector cell Fc receptor expression. PMID: 15210744
    11. expression in bacterial cells; isolation and biophysical and structural studies PMID: 16285718
    12. In mice treated with anti-CD20 mAb, development of arthritis was significantly reduced in comparison to control mAb-treated mice PMID: 18354225
    13. involvement of CD20 in calcium influx PMID: 18474602

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor.
  • 蛋白家族：
    MS4A family
  • 数据库链接：

    KEGG: mmu:12482

    STRING: 10090.ENSMUSP00000126422

    UniGene: Mm.4046