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MUC20 Antibody

  • 货号：
    CSB-PA822693LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
      All lanes: MUC20 antibody at 5.6µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 72, 69 kDa
      Observed band size: 72 kDa
    • IHC image of CSB-PA822693LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA822693LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MUC20 Polyclonal antibody
  • Uniprot No.：
    Q8N307
  • 基因名：
    MUC20
  • 别名：
    MUC 20 antibody; MUC-20 antibody; Muc20 antibody; MUC20_HUMAN antibody; Mucin 20 antibody; Mucin 20, cell surface associated antibody; Mucin-20 antibody; Transmembrane mucin MUC20S antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Mucin-20 protein (569-657AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MUC20 Antibody (CSB-PA822693LA01HU)，的标记方式是Non-conjugated。对于MUC20 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA822693LB01HU MUC20 Antibody, HRP conjugated ELISA
    FITC CSB-PA822693LC01HU MUC20 Antibody, FITC conjugated
    Biotin CSB-PA822693LD01HU MUC20 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
  • 基因功能参考文献：
    1. High MUC20 expression is associated wit response to chemotherapy in esophageal squamous cell carcinoma. PMID: 26673820
    2. Results suggest that MUC20 enhances aggressive behaviors of EOC cells by activating integrin beta1 signaling and provide novel insights into the role of MUC20 in ovarian cancer metastasis. PMID: 26616226
    3. MUC20 is a novel transmembrane mucin expressed by the human corneal and conjunctival epithelia, and suggest that differential expression of MUC20 during differentiation has a role in maintaining ocular surface homeostasis. PMID: 25168902
    4. MUC20 is expressed in recurrent colorectal neoplasms and may have a role in poor outcome PMID: 23787019
    5. Results suggest that MUC20 is a novel regulator of the Met signaling cascade which has a role in suppression of the Grb2-Ras pathway. PMID: 15314156

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  • 亚细胞定位：
    Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane.
  • 组织特异性：
    Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with th
  • 数据库链接：

    HGNC: 23282

    OMIM: 610360

    KEGG: hsa:200958

    STRING: 9606.ENSP00000396774

    UniGene: Hs.308992