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  4. Recombinant Human Mucin-20 (MUC20)

Recombinant Human Mucin-20 (MUC20)

  • 货号：
    CSB-YP822693HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP822693HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP822693HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP822693HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP822693HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MUC20
  • Uniprot No.：
  • 别名：
    MUC 20; MUC-20; Muc20; MUC20_HUMAN; Mucin 20; Mucin 20, cell surface associated; Mucin-20; Transmembrane mucin MUC20S
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-709
  • 氨基酸序列
    GPSTR RADTAMTTDD TEVPAMTLAP GHAALETQTL SAETSSRAST PAGPIPEAET RGAKRISPAR ETRSFTKTSP NFMVLIATSV ETSAASGSPE GAGMTTVQTI TGSDPREAIF DTLCTDDSSE EAKTLTMDIL TLAHTSTEAK GLSSESSASS DSPHPVITPS RASESSASSD GPHPVITPSR ASESSASSDG PHPVITPSRA SESSASSDGP HPVITPSRAS ESSASSDGPH PVITPSRASE SSASSDGPHP VITPSRASES SASSDGPHPV ITPSRASESS ASSDGPHPVI TPSRASESSA SSDGPHPVIT PSRASESSAS SDGLHPVITP SRASESSASS DGPHPVITPS RASESSASSD GPHPVITPSW SPGSDVTLLA EALVTVTNIE VINCSITEIE TTTSSIPGAS DTDLIPTEGV KASSTSDPPA LPDSTEAKPH ITEVTASAET LSTAGTTESA APDATVGTPL PTNSATEREV TAPGATTLSG ALVTVSRNPL EETSALSVET PSYVKVSGAA PVSIEAGSAV GKTTSFAGSS ASSYSPSEAA LKNFTPSETP TMDIATKGPF PTSRDPLPSV PPTTTNSSRG TNSTLAKITT SAKTTMKPPT ATPTTARTRP TTDVSAGENG GFLLLRLSVA SPEDLTDPRV AERLMQQLHR ELHAHAPHFQ VSLLRVRRG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
  • 基因功能参考文献：
    1. High MUC20 expression is associated wit response to chemotherapy in esophageal squamous cell carcinoma. PMID: 26673820
    2. Results suggest that MUC20 enhances aggressive behaviors of EOC cells by activating integrin beta1 signaling and provide novel insights into the role of MUC20 in ovarian cancer metastasis. PMID: 26616226
    3. MUC20 is a novel transmembrane mucin expressed by the human corneal and conjunctival epithelia, and suggest that differential expression of MUC20 during differentiation has a role in maintaining ocular surface homeostasis. PMID: 25168902
    4. MUC20 is expressed in recurrent colorectal neoplasms and may have a role in poor outcome PMID: 23787019
    5. Results suggest that MUC20 is a novel regulator of the Met signaling cascade which has a role in suppression of the Grb2-Ras pathway. PMID: 15314156

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  • 亚细胞定位：
    Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane.
  • 组织特异性：
    Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with th
  • 数据库链接：

    HGNC: 23282

    OMIM: 610360

    KEGG: hsa:200958

    STRING: 9606.ENSP00000396774

    UniGene: Hs.308992