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MLLT11 Antibody

  • 货号：
    CSB-PA618752LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of SH-SY5Y cells with CSB-PA618752LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MLLT11 Polyclonal antibody
  • Uniprot No.：
    Q13015
  • 基因名：
    MLLT11
  • 别名：
    AF1Q antibody; AF1Q_HUMAN antibody; ALL1 fused gene from chromosome 1q antibody; MLLT 11 antibody; MLLT11 antibody; Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog; Drosophila) translocated to 11 antibody; Protein AF1q antibody; RP11 316M1.10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein AF1q protein (1-90AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MLLT11 Antibody (CSB-PA618752LA01HU)，的标记方式是Non-conjugated。对于MLLT11 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA618752LB01HU MLLT11 Antibody, HRP conjugated ELISA
    FITC CSB-PA618752LC01HU MLLT11 Antibody, FITC conjugated
    Biotin CSB-PA618752LD01HU MLLT11 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate.
  • 基因功能参考文献：
    1. AF1q was up-regulated in human colorectal cancer tissues, and that this up-regulation was associated with tumor metastasis. AF1q contributes to CRC tumorigenesis through the activation of the AKT signaling pathway. PMID: 28475127
    2. Data show that MLLT11/AF1q-induced PDGFR signaling enhanced STAT3 activity through Src kinase activation. PMID: 27259262
    3. AF1q was significantly lower in borderline ovarian tumors (i.e., tumors of low malignant potential without stromal invasion) than in invasive tumors, thus corroborating the association between high AF1q expression and increased migratory/invasive cell behavior and confirming its potential role in ovarian cancer progression. PMID: 28423573
    4. These results suggest that AF1q would have a role as an enhancer in generation of stem-like population through activation of Wnt signaling pathway. PMID: 28188793
    5. Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties. PMID: 26079538
    6. Results demonstrate that AF1q gene transcription is regulated by REST through direct binding at -383 to -363 bp of AF1q promoter. PMID: 26341630
    7. AF1Q had a KFERQ-like motif. PMID: 24880125
    8. AF1q plays a role in the onset of basal apoptosis in ovarian cancer cells, thus providing new information about the activity of this protein whose biologic functions are mostly unknown PMID: 22761939
    9. Using in vitro assays based on either forced expression or shRNA-mediated silencing of AF1q, the study provides evidence that the protein promotes T- over B-cell differentiation in multipotent hematopoietic progenitors. PMID: 21715312
    10. AF1q up-regulation of BAD is through its effect on NF-kappaB and this may hint of its oncogenic mechanism in cancer. PMID: 20596645
    11. The ectopic expression of human AF1q triggered the expression of the neuronal marker TuJ1 in non-neuronal human embryonic kidney (HEK) cells. PMID: 15530661
    12. overexpression of AF1Q leads to more progression in human breast cancer PMID: 17929166
    13. The study provides the first evidence that AF1q plays a critical role in the regulation of apoptosis and drug resistance. PMID: 18852119
    14. high AF1q expression is a poor prognostic marker for adult patients with normal cytogenetics acute myeloid leukemia PMID: 19396856

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  • 相关疾病：
    A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.
  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    MLLT11 family
  • 组织特异性：
    Expressed in myoepithelial cells of normal breast tissue (at protein level). Highly expressed in thymus. Expressed in colon, small intestine, prostate and ovary. Not detected in peripheral blood lymphocytes and spleen.
  • 数据库链接：

    HGNC: 16997

    OMIM: 604684

    KEGG: hsa:10962

    STRING: 9606.ENSP00000357917

    UniGene: Hs.75823