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  4. Recombinant Human Protein AF1q (MLLT11)

Recombinant Human Protein AF1q (MLLT11)

  • 货号：
    CSB-YP618752HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP618752HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP618752HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP618752HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP618752HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MLLT11
  • Uniprot No.：
  • 别名：
    AF1Q; AF1Q_HUMAN; ALL1 fused gene from chromosome 1q; MLLT 11; MLLT11; Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog; Drosophila) translocated to 11; Protein AF1q; RP11 316M1.10
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-90
  • 氨基酸序列
    MRDPVSSQYS SFLFWRMPIP ELDLSELEGL GLSDTATYKV KDSSVGKMIG QATAADQEKN PEGDGLLEYS TFNFWRAPIA SIHSFELDLL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate.
  • 基因功能参考文献：
    1. AF1q was up-regulated in human colorectal cancer tissues, and that this up-regulation was associated with tumor metastasis. AF1q contributes to CRC tumorigenesis through the activation of the AKT signaling pathway. PMID: 28475127
    2. Data show that MLLT11/AF1q-induced PDGFR signaling enhanced STAT3 activity through Src kinase activation. PMID: 27259262
    3. AF1q was significantly lower in borderline ovarian tumors (i.e., tumors of low malignant potential without stromal invasion) than in invasive tumors, thus corroborating the association between high AF1q expression and increased migratory/invasive cell behavior and confirming its potential role in ovarian cancer progression. PMID: 28423573
    4. These results suggest that AF1q would have a role as an enhancer in generation of stem-like population through activation of Wnt signaling pathway. PMID: 28188793
    5. Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties. PMID: 26079538
    6. Results demonstrate that AF1q gene transcription is regulated by REST through direct binding at -383 to -363 bp of AF1q promoter. PMID: 26341630
    7. AF1Q had a KFERQ-like motif. PMID: 24880125
    8. AF1q plays a role in the onset of basal apoptosis in ovarian cancer cells, thus providing new information about the activity of this protein whose biologic functions are mostly unknown PMID: 22761939
    9. Using in vitro assays based on either forced expression or shRNA-mediated silencing of AF1q, the study provides evidence that the protein promotes T- over B-cell differentiation in multipotent hematopoietic progenitors. PMID: 21715312
    10. AF1q up-regulation of BAD is through its effect on NF-kappaB and this may hint of its oncogenic mechanism in cancer. PMID: 20596645
    11. The ectopic expression of human AF1q triggered the expression of the neuronal marker TuJ1 in non-neuronal human embryonic kidney (HEK) cells. PMID: 15530661
    12. overexpression of AF1Q leads to more progression in human breast cancer PMID: 17929166
    13. The study provides the first evidence that AF1q plays a critical role in the regulation of apoptosis and drug resistance. PMID: 18852119
    14. high AF1q expression is a poor prognostic marker for adult patients with normal cytogenetics acute myeloid leukemia PMID: 19396856

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  • 相关疾病：
    A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.
  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    MLLT11 family
  • 组织特异性：
    Expressed in myoepithelial cells of normal breast tissue (at protein level). Highly expressed in thymus. Expressed in colon, small intestine, prostate and ovary. Not detected in peripheral blood lymphocytes and spleen.
  • 数据库链接：

    HGNC: 16997

    OMIM: 604684

    KEGG: hsa:10962

    STRING: 9606.ENSP00000357917

    UniGene: Hs.75823