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  4. MATK Antibody

MATK Antibody

  • 货号：
    CSB-PA010068
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P42679
  • 基因名：
  • 别名：
    CHK antibody; Csk homologous kinase antibody; Csk type protein tyrosine kinase antibody; CTK antibody; DKFZp434N1212 antibody; EC 2.7.10.2 antibody; Hematopoietic consensus tyrosine lacking kinase antibody; Hematopoietic consensus tyrosine-lacking kinase antibody; HHYLTK antibody; Hydroxyaryl protein kinase antibody; HYL antibody; HYL tyrosine kinase antibody; HYLTK antibody; Leukocyte carboxyl terminal src kinase related antibody; Lsk antibody; matK antibody; MATK_HUMAN antibody; Megakaryocyte associated tyrosine kinase antibody; Megakaryocyte associated tyrosine protein kinase antibody; Megakaryocyte-associated tyrosine-protein kinase antibody; MGC1708 antibody; MGC2101 antibody; Protein kinase HYL antibody; Tyrosine kinase MATK antibody; Tyrosine protein kinase CTK antibody; Tyrosine-protein kinase CTK antibody; Tyrosylprotein kinase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Lsk.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
  • 基因功能参考文献：
    1. After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1. PMID: 21799000
    2. ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines PMID: 12122014
    3. Overexpression of the Csk homologous kinase facilitates phosphorylation of akt/protein kinase b in breast neoplasms PMID: 12429987
    4. CHK Leu223 stabilizes the movement of the alphaC-helix of the protein tyrosine kinase PMID: 12782282
    5. Loss of CHK expression is associated with human brain tumors PMID: 15329911
    6. Nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation. PMID: 15748901
    7. striking functional differences between the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 domains PMID: 15890649
    8. This study describes for the first time the Src-independent actions of CHK and provides novel insights into CHK function in neural cells. PMID: 16168623
    9. Matk/CHK is not functionally redundant with Csk, and this tyrosine kinase plays an important role as a regulator of immunologic responses PMID: 16574955
    10. Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation. PMID: 16707123
    11. Progesterone increases MATK in mast cells and reducs cell proliferation. PMID: 17492661
    12. These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells. PMID: 17934522
    13. CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma. PMID: 18292939

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  • 亚细胞定位：
    Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, CSK subfamily
  • 组织特异性：
    Expressed in various myeloid cell lines, detected in brain and lung.
  • 数据库链接：

    HGNC: 6906

    OMIM: 600038

    KEGG: hsa:4145

    STRING: 9606.ENSP00000378485

    UniGene: Hs.631845