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  4. Recombinant Human Megakaryocyte-associated tyrosine-protein kinase (MATK)

Recombinant Human Megakaryocyte-associated tyrosine-protein kinase (MATK)

  • 中文名称：
    人MATK重组蛋白
  • 货号：
    CSB-YP013519HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MATK重组蛋白
  • 货号：
    CSB-EP013519HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MATK重组蛋白
  • 货号：
    CSB-EP013519HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MATK重组蛋白
  • 货号：
    CSB-BP013519HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MATK重组蛋白
  • 货号：
    CSB-MP013519HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CHK ; Csk homologous kinase; Csk type protein tyrosine kinase; CTK ; DKFZp434N1212 ; EC 2.7.10.2; Hematopoietic consensus tyrosine lacking kinase; Hematopoietic consensus tyrosine-lacking kinase; HHYLTK ; Hydroxyaryl protein kinase ; HYL ; HYL tyrosine kinase; HYLTK ; Leukocyte carboxyl terminal src kinase related; Lsk ; matK; MATK_HUMAN; Megakaryocyte associated tyrosine kinase; Megakaryocyte associated tyrosine protein kinase; Megakaryocyte-associated tyrosine-protein kinase; MGC1708 ; MGC2101 ; Protein kinase HYL; Tyrosine kinase MATK; Tyrosine protein kinase CTK; Tyrosine-protein kinase CTK; Tyrosylprotein kinase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-507
  • 氨基酸序列
    MAGRGSLVSW RAFHGCDSAE ELPRVSPRFL RAWHPPPVSA RMPTRRWAPG TQCITKCEHT RPKPGELAFR KGDVVTILEA CENKSWYRVK HHTSGQEGLL AAGALREREA LSADPKLSLM PWFHGKISGQ EAVQQLQPPE DGLFLVRESA RHPGDYVLCV SFGRDVIHYR VLHRDGHLTI DEAVFFCNLM DMVEHYSKDK GAICTKLVRP KRKHGTKSAE EELARAGWLL NLQHLTLGAQ IGEGEFGAVL QGEYLGQKVA VKNIKCDVTA QAFLDETAVM TKMQHENLVR LLGVILHQGL YIVMEHVSKG NLVNFLRTRG RALVNTAQLL QFSLHVAEGM EYLESKKLVH RDLAARNILV SEDLVAKVSD FGLAKAERKG LDSSRLPVKW TAPEALKHGK FTSKSDVWSF GVLLWEVFSY GRAPYPKMSL KEVSEAVEKG YRMEPPEGCP GPVHVLMSSC WEAEPARRPP FRKLAEKLAR ELRSAGAPAS VSGQDADGST SPRSQEP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
  • 基因功能参考文献：
    1. After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1. PMID: 21799000
    2. ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines PMID: 12122014
    3. Overexpression of the Csk homologous kinase facilitates phosphorylation of akt/protein kinase b in breast neoplasms PMID: 12429987
    4. CHK Leu223 stabilizes the movement of the alphaC-helix of the protein tyrosine kinase PMID: 12782282
    5. Loss of CHK expression is associated with human brain tumors PMID: 15329911
    6. Nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation. PMID: 15748901
    7. striking functional differences between the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 domains PMID: 15890649
    8. This study describes for the first time the Src-independent actions of CHK and provides novel insights into CHK function in neural cells. PMID: 16168623
    9. Matk/CHK is not functionally redundant with Csk, and this tyrosine kinase plays an important role as a regulator of immunologic responses PMID: 16574955
    10. Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation. PMID: 16707123
    11. Progesterone increases MATK in mast cells and reducs cell proliferation. PMID: 17492661
    12. These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells. PMID: 17934522
    13. CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma. PMID: 18292939

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  • 亚细胞定位：
    Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, CSK subfamily
  • 组织特异性：
    Expressed in various myeloid cell lines, detected in brain and lung.
  • 数据库链接：

    HGNC: 6906

    OMIM: 600038

    KEGG: hsa:4145

    STRING: 9606.ENSP00000378485

    UniGene: Hs.631845