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Loxl1 Antibody

  • 货号：
    CSB-PA013040LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Loxl1 Polyclonal antibody
  • Uniprot No.：
    P97873
  • 基因名：
    Loxl1
  • 别名：
    Loxl1 antibody; Lox2 antibody; Loxl antibody; Lysyl oxidase homolog 1 antibody; EC 1.4.3.- antibody; Lysyl oxidase 2 antibody; Lysyl oxidase-like protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse Lysyl oxidase homolog 1 protein (95-607AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Loxl1 Antibody (CSB-PA013040LA01MO)，的标记方式是Non-conjugated。对于Loxl1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA013040LB01MO Loxl1 Antibody, HRP conjugated ELISA
    FITC CSB-PA013040LC01MO Loxl1 Antibody, FITC conjugated
    Biotin CSB-PA013040LD01MO Loxl1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Active on elastin and collagen substrates.
  • 基因功能参考文献：
    1. findings strongly suggested that elastin crosslinking and LOXL1 were co-associated with liver cirrhosis, while selective inhibition of LOXL1 arrested disease progression by reducing crosslinking of elastin. PMID: 29366776
    2. LOXL1-/- mutant mice develop appendicular and axial skeletal phenotypes characterized by decreased bone volume fraction and compromised trabecular microstructure, predominantly in females PMID: 26538021
    3. Elimination of LOXL1 in mice impairs the blood-aqueous humor barrier in the ocular anterior segment and causes lens abnormalities consistent with cataract formation, but does not result in deposition of macromolecular material or glaucoma. PMID: 24425853
    4. There is a possible fundamental role of LOXL-1 in cardiac hypertrophy. PMID: 22763477
    5. loxl appears non-allelic to rough coat in mice; heart- and skin-specific downregulation of LOXL in rough coat mice, however, may contribute to the extracellular matrix alterations and the rough coat phenotype PMID: 15482472
    6. Data report that cells in the hippocampal granule cell layer of LOXL -/- mice have significantly smaller somas and muted long-term potentiation compared to LOXL +/+ mice. PMID: 16157454
    7. LOXL1 deficiency caused failure of elastic fiber homeostasis leading to pelvic floor disorders PMID: 16436666
    8. LOXL1 (lysyl oxidase-like 1) mutation results in a global defect in connective tissues and correlates with altered biomechanical behavior of the vagina and supportive tissues PMID: 18265927
    9. LOXL1-KO lower urogenital tract anatomical and functional phenotype resembles female pelvic floor dysfunction in humans. Elastin disorganization may lead to such functional abnormalities. PMID: 18495804
    10. Loxl1(-/-) males bred with control females demonstrated relative fecundity values intermediate between Loxl1(-/-) pairs (lowest fecundity) and control pairs (highest fecundity), suggesting a component of male-factor infertility. PMID: 19201700

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  • 亚细胞定位：
    Secreted, extracellular space.
  • 蛋白家族：
    Lysyl oxidase family
  • 数据库链接：

    KEGG: mmu:16949

    STRING: 10090.ENSMUSP00000057406

    UniGene: Mm.250492