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  4. Recombinant Mouse Lysyl oxidase homolog 1 (Loxl1)

Recombinant Mouse Lysyl oxidase homolog 1 (Loxl1)

  • 货号：
    CSB-BP013040MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-EP013040MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-MP013040MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Name:Loxl1 Synonyms:Lox2, Loxl
  • Uniprot No.：
  • 别名：
    Loxl1; Lox2; Loxl; Lysyl oxidase homolog 1; EC 1.4.3.-; Lysyl oxidase 2; Lysyl oxidase-like protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    95-607
  • 氨基酸序列
    RQAPSL PLPGRVGSDT VRGQTRHPFG FGQVPDNWRE VAVGDSTGMA RARTSVSQQR HGGSASSSVS ASAFATTYRQ PSPYPQQFPY PQAPFVNQYE NYDPASRTYE QGYVYYRGAG GGMGAGAAAV ASAGVIYPFQ PRARYEDYGG GGGEEQPEYP AQGFYPAPER PYVPQPQPQP QPQPQPQPQP SDGLDRRYSH SLYNEGTPGF EQAYPDPSTD VSQAPAGAGG TYGGAGDPRL GWYPPYAANV PPEAYVPPRA VEPQPPFRVL EPPYLPVRSS DAPSQGGERN GAQQGRLSVG SVYRPNQNGR GLPDLVPDPN YVQASTYVQR AHLYSLRCAA EEKCLASTAY APEATDYDLR VLLRFPQRVK NQGTADFLPN RPRHTWEWHS CHQHYHSMDE FSHYDLLDAS TGKKVAEGHK ASFCLEDSTC DFGNLKRYAC TSHTQGLSPG CYDTYNADID CQWIDITDVQ PGNYILKVHV NPKYIVLESD FTNNVVRCNI HYTGRYVSTT NCKIVQS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Active on elastin and collagen substrates.
  • 基因功能参考文献：
    1. findings strongly suggested that elastin crosslinking and LOXL1 were co-associated with liver cirrhosis, while selective inhibition of LOXL1 arrested disease progression by reducing crosslinking of elastin. PMID: 29366776
    2. LOXL1-/- mutant mice develop appendicular and axial skeletal phenotypes characterized by decreased bone volume fraction and compromised trabecular microstructure, predominantly in females PMID: 26538021
    3. Elimination of LOXL1 in mice impairs the blood-aqueous humor barrier in the ocular anterior segment and causes lens abnormalities consistent with cataract formation, but does not result in deposition of macromolecular material or glaucoma. PMID: 24425853
    4. There is a possible fundamental role of LOXL-1 in cardiac hypertrophy. PMID: 22763477
    5. loxl appears non-allelic to rough coat in mice; heart- and skin-specific downregulation of LOXL in rough coat mice, however, may contribute to the extracellular matrix alterations and the rough coat phenotype PMID: 15482472
    6. Data report that cells in the hippocampal granule cell layer of LOXL -/- mice have significantly smaller somas and muted long-term potentiation compared to LOXL +/+ mice. PMID: 16157454
    7. LOXL1 deficiency caused failure of elastic fiber homeostasis leading to pelvic floor disorders PMID: 16436666
    8. LOXL1 (lysyl oxidase-like 1) mutation results in a global defect in connective tissues and correlates with altered biomechanical behavior of the vagina and supportive tissues PMID: 18265927
    9. LOXL1-KO lower urogenital tract anatomical and functional phenotype resembles female pelvic floor dysfunction in humans. Elastin disorganization may lead to such functional abnormalities. PMID: 18495804
    10. Loxl1(-/-) males bred with control females demonstrated relative fecundity values intermediate between Loxl1(-/-) pairs (lowest fecundity) and control pairs (highest fecundity), suggesting a component of male-factor infertility. PMID: 19201700

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  • 亚细胞定位：
    Secreted, extracellular space.
  • 蛋白家族：
    Lysyl oxidase family
  • 数据库链接：

    KEGG: mmu:16949

    STRING: 10090.ENSMUSP00000057406

    UniGene: Mm.250492