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LYPLAL1 Antibody

  • 货号：
    CSB-PA736204LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA736204LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA736204LA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA736204LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LYPLAL1 Polyclonal antibody
  • Uniprot No.：
    Q5VWZ2
  • 基因名：
    LYPLAL1
  • 别名：
    BC027340 antibody; FLJ99730 antibody; KIAA1238 antibody; LYPL1_HUMAN antibody; LYPLAL1 antibody; Lysophospholipase like 1 antibody; Lysophospholipase-like protein 1 antibody; MGC28394 antibody; OTTHUMP00000035229 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Lysophospholipase-like protein 1 protein (2-237AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LYPLAL1 Antibody (CSB-PA736204LA01HU)，的标记方式是Non-conjugated。对于LYPLAL1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA736204LB01HU LYPLAL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA736204LC01HU LYPLAL1 Antibody, FITC conjugated
    Biotin CSB-PA736204LD01HU LYPLAL1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.
  • 基因功能参考文献：
    1. Novel LYPLAL1 SNP rs2605100 is associated with childhood hypertension adjusted by obesity. PMID: 28645872
    2. The LYPLAL1 genotype is associated with differences in eating behavior and loss of extensive body weight following Roux-en-Y gastric bypass (RYGB) surgery. Genotyping and the use of eating behavior-related questionnaires may help to estimate the RYGB-associated therapy success. PMID: 27181159
    3. Data provide evidence that variants of MC4R and LYPLAL1 modulate body fat distribution with sexual dimorphism in a Chinese population. PMID: 26848030
    4. Our results suggest that LYPLAL1 rs4846567 and NISCH rs6784615 may influence fat distribution in the Japanese population. PMID: 23221025
    5. genetic association studies in Danish population: Quantitative metabolic phenotypes in obesity are associated with SNP in various genes: LYPLAL1 (rs4846567) is associated with waist-hip ratio and insulin sensitivity in women. PMID: 21953277
    6. Gene-treatment interactions were observed for short-term weight loss. (LYPLAL1 rs2605100, Plifestyle*SNP = 0.032) PMID: 22179955
    7. LYPLAL1 exhibits neither phospholipase nor triacylglycerol lipase activity, but rather accepts short-chain substrates PMID: 22052940
    8. central obesity-associated variants in LYPLAL1, NRXN3, MSRA, and TFAP2B PMID: 21674055
    9. TFAP2B, LYPLAL1 and MSRA are associated with adiposity and fat distribution. PMID: 19557161

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasm, cytosol.; [Isoform 2]: Cytoplasm, cytosol.
  • 蛋白家族：
    AB hydrolase superfamily, AB hydrolase 2 family
  • 数据库链接：

    HGNC: 20440

    OMIM: 616548

    KEGG: hsa:127018

    STRING: 9606.ENSP00000355895

    UniGene: Hs.657617