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  4. Recombinant Human Lysophospholipase-like protein 1 (LYPLAL1)

Recombinant Human Lysophospholipase-like protein 1 (LYPLAL1)

  • 货号：
    CSB-YP736204HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP736204HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP736204HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP736204HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP736204HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LYPLAL1
  • Uniprot No.：
  • 别名：
    BC027340; FLJ99730; KIAA1238; LYPL1_HUMAN; LYPLAL1; Lysophospholipase like 1; Lysophospholipase-like protein 1; MGC28394; OTTHUMP00000035229
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-237
  • 氨基酸序列
    AAASGSVLQ RCIVSPAGRH SASLIFLHGS GDSGQGLRMW IKQVLNQDLT FQHIKIIYPT APPRSYTPMK GGISNVWFDR FKITNDCPEH LESIDVMCQV LTDLIDEEVK SGIKKNRILI GGFSMGGCMA IHLAYRNHQD VAGVFALSSF LNKASAVYQA LQKSNGVLPE LFQCHGTADE LVLHSWAEET NSMLKSLGVT TKFHSFPNVY HELSKTELDI LKLWILTKLP GEMEKQK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.
  • 基因功能参考文献：
    1. Novel LYPLAL1 SNP rs2605100 is associated with childhood hypertension adjusted by obesity. PMID: 28645872
    2. The LYPLAL1 genotype is associated with differences in eating behavior and loss of extensive body weight following Roux-en-Y gastric bypass (RYGB) surgery. Genotyping and the use of eating behavior-related questionnaires may help to estimate the RYGB-associated therapy success. PMID: 27181159
    3. Data provide evidence that variants of MC4R and LYPLAL1 modulate body fat distribution with sexual dimorphism in a Chinese population. PMID: 26848030
    4. Our results suggest that LYPLAL1 rs4846567 and NISCH rs6784615 may influence fat distribution in the Japanese population. PMID: 23221025
    5. genetic association studies in Danish population: Quantitative metabolic phenotypes in obesity are associated with SNP in various genes: LYPLAL1 (rs4846567) is associated with waist-hip ratio and insulin sensitivity in women. PMID: 21953277
    6. Gene-treatment interactions were observed for short-term weight loss. (LYPLAL1 rs2605100, Plifestyle*SNP = 0.032) PMID: 22179955
    7. LYPLAL1 exhibits neither phospholipase nor triacylglycerol lipase activity, but rather accepts short-chain substrates PMID: 22052940
    8. central obesity-associated variants in LYPLAL1, NRXN3, MSRA, and TFAP2B PMID: 21674055
    9. TFAP2B, LYPLAL1 and MSRA are associated with adiposity and fat distribution. PMID: 19557161

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasm, cytosol.; [Isoform 2]: Cytoplasm, cytosol.
  • 蛋白家族：
    AB hydrolase superfamily, AB hydrolase 2 family
  • 数据库链接：

    HGNC: 20440

    OMIM: 616548

    KEGG: hsa:127018

    STRING: 9606.ENSP00000355895

    UniGene: Hs.657617