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LMX1A Antibody

  • 货号：
    CSB-PA848414LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA848414LA01HU at dilution of 1:100
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, Hela whole cell lysate, A549 whole cell lysate, K562 whole cell lysate, HL60 whole cell lysate
      All lanes: LMX1A antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 43, 15 kDa
      Observed band size: 43 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LMX1A Polyclonal antibody
  • Uniprot No.：
    Q8TE12
  • 基因名：
    LMX1A
  • 别名：
    HGNC:6653 antibody; LIM homeobox protein 1.1 antibody; LIM homeobox transcription factor 1 alpha antibody; LIM homeobox transcription factor 1-alpha antibody; LIM/homeobox protein 1.1 antibody; LIM/homeobox protein LMX1A antibody; LMX 1 antibody; LMX 1.1 antibody; LMX 1A antibody; LMX-1.1 antibody; LMX1 antibody; LMX1.1 antibody; LMX1A antibody; LMX1A_HUMAN antibody; MGC87616 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human LIM homeobox transcription factor 1-alpha protein (9-86AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，LMX1A Antibody (CSB-PA848414LA01HU)，的标记方式是Non-conjugated。对于LMX1A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA848414LB01HU LMX1A Antibody, HRP conjugated ELISA
    FITC CSB-PA848414LC01HU LMX1A Antibody, FITC conjugated
    Biotin CSB-PA848414LD01HU LMX1A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.
  • 基因功能参考文献：
    1. Study revealed an anti-metastatic role of LMX1A in gastric cancer which is mediated by the negative regulation of beta-catenin signaling target genes. PMID: 27061089
    2. Polymorphisms of dopamine pathway gene aLMX1A is associated with cognitive performance in Bipolar disorder. PMID: 26534905
    3. Lmx1a and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars compacta and the ventral tegmental area. [Review] PMID: 26526610
    4. SNPs of the LMX1A gene might be associated with the susceptibility to congenital scoliosis and different clinical phenotypes in the Chinese Han population. PMID: 25099324
    5. To our best knowledge, this is the first report demonstrating the application of TAT-LMX1A recombinant protein to enhance hESC differentiation to DA as shown by the expression of DA specific makers. PMID: 25380985
    6. LMX1A is weakly methylated in cervical adenocarcinomas compared with controls, in a metastatic stage of cervical cancer. PMID: 24407576
    7. higher expression is associated with more advanced neoplasm staging in Chinese patients with pancreatic ductal adenocarcinomas PMID: 23165334
    8. these data imply that Sp1 and EZH2 may activate LMX1A expression upon oncogenic stress during cervical cancer development. PMID: 24018208
    9. Higher immunostaining intensity for OPN and LMX1A correlated with WHO grades for meningiomas and some gliomas. Contrary to our expectations, LMX1A staining in WHO grade IV gliomas was shown to be weaker than in WHO grade III tumours. PMID: 22882568
    10. The Lmx1a can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching. PMID: 21624811
    11. One single nucleotide polymorphisms of lmx1a was strongly associated with the magnitude of training-related gains in verbal working memory PMID: 21435346
    12. LMX1A may be a potential biomarker for gastric cancer. PMID: 21159062
    13. Genetic variation in LMX1A may increase the risk of developing schizophrenia. PMID: 20570600
    14. Did not find evidence for association of any LMX1A SNPs with type 2 diabetes mellitus (T2DM) and conclude that LMX1A does not contribute significantly to T2DM etiology in Pima Indians. PMID: 12062816
    15. Lmx1a expression is necessary for the expression of bone morphogenetic protein (BMP), and for the normal generation and differentiation of the dorsal-most spinal cord neurons, the dl1 interneurons. PMID: 15183721
    16. Lmx1a may be critical to the development of midbrain dopamine neurons from human embryonic stem cells. PMID: 18832589
    17. Data show that three single nucleotide polymor in LMX1A and one in LMX1B are associated with Parkinson's disease. PMID: 19189040

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4AB is expressed in testis.
  • 数据库链接：

    HGNC: 6653

    OMIM: 600298

    KEGG: hsa:4009

    STRING: 9606.ENSP00000294816

    UniGene: Hs.667312