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  4. Recombinant Human LIM homeobox transcription factor 1-alpha (LMX1A)

Recombinant Human LIM homeobox transcription factor 1-alpha (LMX1A)

  • 中文名称：
    人LMX1A重组蛋白
  • 货号：
    CSB-YP848414HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LMX1A重组蛋白
  • 货号：
    CSB-EP848414HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LMX1A重组蛋白
  • 货号：
    CSB-EP848414HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LMX1A重组蛋白
  • 货号：
    CSB-BP848414HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LMX1A重组蛋白
  • 货号：
    CSB-MP848414HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LMX1A
  • Uniprot No.：
  • 别名：
    HGNC:6653; LIM homeobox protein 1.1; LIM homeobox transcription factor 1 alpha; LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1; LIM/homeobox protein LMX1A; LMX 1; LMX 1.1; LMX 1A; LMX-1.1; LMX1; LMX1.1; LMX1A; LMX1A_HUMAN; MGC87616
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-382
  • 氨基酸序列
    MLDGLKMEEN FQSAIDTSAS FSSLLGRAVS PKSVCEGCQR VILDRFLLRL NDSFWHEQCV QCASCKEPLE TTCFYRDKKL YCKYDYEKLF AVKCGGCFEA IAPNEFVMRA QKSVYHLSCF CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK ERELLSLVSP AASDSGKSDD EESLCKSAHG AGKGTAEEGK DHKRPKRPRT ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ VWFQNQRAKM KKLARRQQQQ QQDQQNTQRL SSAQTNGGGS AGMEGIMNPY TALPTPQQLL AIEQSVYSSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD CFLATSEAGP LQSRVGNPID HLYSMQNSYF TS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.
  • 基因功能参考文献：
    1. Study revealed an anti-metastatic role of LMX1A in gastric cancer which is mediated by the negative regulation of beta-catenin signaling target genes. PMID: 27061089
    2. Polymorphisms of dopamine pathway gene aLMX1A is associated with cognitive performance in Bipolar disorder. PMID: 26534905
    3. Lmx1a and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars compacta and the ventral tegmental area. [Review] PMID: 26526610
    4. SNPs of the LMX1A gene might be associated with the susceptibility to congenital scoliosis and different clinical phenotypes in the Chinese Han population. PMID: 25099324
    5. To our best knowledge, this is the first report demonstrating the application of TAT-LMX1A recombinant protein to enhance hESC differentiation to DA as shown by the expression of DA specific makers. PMID: 25380985
    6. LMX1A is weakly methylated in cervical adenocarcinomas compared with controls, in a metastatic stage of cervical cancer. PMID: 24407576
    7. higher expression is associated with more advanced neoplasm staging in Chinese patients with pancreatic ductal adenocarcinomas PMID: 23165334
    8. these data imply that Sp1 and EZH2 may activate LMX1A expression upon oncogenic stress during cervical cancer development. PMID: 24018208
    9. Higher immunostaining intensity for OPN and LMX1A correlated with WHO grades for meningiomas and some gliomas. Contrary to our expectations, LMX1A staining in WHO grade IV gliomas was shown to be weaker than in WHO grade III tumours. PMID: 22882568
    10. The Lmx1a can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching. PMID: 21624811
    11. One single nucleotide polymorphisms of lmx1a was strongly associated with the magnitude of training-related gains in verbal working memory PMID: 21435346
    12. LMX1A may be a potential biomarker for gastric cancer. PMID: 21159062
    13. Genetic variation in LMX1A may increase the risk of developing schizophrenia. PMID: 20570600
    14. Did not find evidence for association of any LMX1A SNPs with type 2 diabetes mellitus (T2DM) and conclude that LMX1A does not contribute significantly to T2DM etiology in Pima Indians. PMID: 12062816
    15. Lmx1a expression is necessary for the expression of bone morphogenetic protein (BMP), and for the normal generation and differentiation of the dorsal-most spinal cord neurons, the dl1 interneurons. PMID: 15183721
    16. Lmx1a may be critical to the development of midbrain dopamine neurons from human embryonic stem cells. PMID: 18832589
    17. Data show that three single nucleotide polymor in LMX1A and one in LMX1B are associated with Parkinson's disease. PMID: 19189040

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4AB is expressed in testis.
  • 数据库链接：

    HGNC: 6653

    OMIM: 600298

    KEGG: hsa:4009

    STRING: 9606.ENSP00000294816

    UniGene: Hs.667312