LIG3 Antibody

1. The homozygotes of rs1052536 TT were associated with an increased risk for NTDs than CC, and variants of rs1052536 T were associated with an increased risk of Neural Tube Defects. The stratified analysis showed that TT genotype of rs1052536 increased the risk of anencephaly and the T allele significantly increased the risk of cranial Neural Tube Defects. PMID: 30022792
2. single-stranded break repair by human DNA ligase III isoforms reveal biochemical differences from DNA ligase I PMID: 28751376
3. The g.29661G>A and g.29059C>T polymorphisms of LIG3 may play a role in the keratoconus and Fuchs endothelial corneal dystrophy pathogenesis and can be considered as markers in these diseases. PMID: 25817347
4. A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 gene on binding interaction of XRCC1 protein with ligase III. PMID: 26449312
5. In the context of tyrosine kinase-activated leukemias, c-MYC contributes to aberrant DNA repair through downstream targets LIG3 and PARP1 up-regulation. PMID: 25828893
6. Domains constituting the LigIII catalytic core collaborate and are essential for formation of a DNA-bridging intermediate by adenylated LigIII that positions a pair of blunt-ended duplex DNAs for efficient and specific intermolecular ligation. PMID: 26130724
7. there is an absolute requirement for fully functional DNA ligase III (LIG3), but not ligase IV (LIG4), to facilitate the escape from a telomere-driven crisis. PMID: 25127141
8. LIGIII plays a role in additional EJing repair pathway only in the absence of Ku. PMID: 24837021
9. Results show that overexpression of DNA ligase III in mitochondria improves mitochondrial base excision repair and enhances cell survival after oxidative stress. PMID: 24674627
10. data confirm previous work showing that Lig3 is required to maintain mtDNA integrity and function, and highlight a new function of ATM in regulating DNA Lig3 stability and consequently mtDNA repair PMID: 24342190
11. Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway. PMID: 21816818
12. Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy. PMID: 21620500
13. results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1 PMID: 21390132
14. The collective results support a "jackknife model" in which the ZnF loads ligase III onto nicked DNA and conformational changes deliver DNA into the active site. PMID: 20518483
15. The interaction with Lig3alpha is promoted by serine 81 that is located within a putative S/TQ site in the N-terminus domain of TDP1. PMID: 20009512
16. calpain-mediated proteolysis of DNA ligase III plays an essential role in DNA damage-induced cell death in human cells PMID: 11994275
17. In response to DNA damage, DNA ligase IIIalpha translocate from centrosomes to chromosomes. PMID: 15653642
18. XRCC1 stimulates Pol beta strand displacement activity and releases inhibition of Pol beta by DNA-bound Lig III if ligation is prevented. PMID: 16442856
19. the interaction of DNA ligase III and DNA polymerase gamma is required for proper maintenance of the mammalian mitochondrial genome. PMID: 17054425
20. Results describe the activity requirements for DNA ligases III and IV in the pathways of non-homologous DNA end joining. PMID: 17492771
21. key role for XRCC1-DNA ligase IIIalpha in maintenance of genomic integrity by nucleotide excision repair in both dividing and nondividing cells PMID: 17643379
22. analysis of DNA-binding and nick recognition modules in human DNA ligase III PMID: 18238776
23. Data show that CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins XRCC1, DNA polymerase beta, and DNA ligase III. PMID: 18313385
24. siRNA mediated down-regulation of DNA ligase III in human HTD114 cells led to impaired end joining that was mediated by 2-, 3- or 10-bp microhomology. PMID: 18440984
25. altered DNA double-strand break repair in CML cells is caused by the increased activity of an alternative nonhomologous end-joining repair pathway, involving DNA ligase IIIalpha and WRN PMID: 18524993
26. PMID 10207110 showed that translation initiation at the first ATG in the cDNA can lead to a mitochondrially-targeted isoform of the protein. PMID: 10207110

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HGNC: 6600

OMIM: 600940

KEGG: hsa:3980

STRING: 9606.ENSP00000367787

UniGene: Hs.100299