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LHX6 Antibody

  • 货号：
    CSB-PA891795ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA891795ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) LHX6 Polyclonal antibody
  • Uniprot No.：
    Q9UPM6
  • 基因名：
    LHX6
  • 别名：
    LHX 6 antibody; LHX 6.1 antibody; LHX6 antibody; LHX6.1 antibody; LHX6_HUMAN antibody; LIM homeobox 6 antibody; LIM homeobox protein 6 antibody; LIM homeodomain protein 6.1 antibody; LIM/homeobox protein Lhx6 antibody; LIM/homeobox protein Lhx6.1 antibody; MGC119542 antibody; MGC119544 antibody; MGC119545 antibody; OTTHUMP00000064113 antibody; OTTHUMP00000064114 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human LIM/homeobox protein Lhx6 protein (114-363AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.
  • 基因功能参考文献：
    1. that down-regulation of miR-214 may reverse acquired resistance to erlotinib in NSCLC through mediating its direct target gene LHX6 expression. PMID: 28396596
    2. LHX6 inhibits breast cancer cell proliferation and invasion via repression of the Wnt/beta-catenin signaling pathway. PMID: 26129710
    3. LHX6 is a putative tumour suppressor gene with epigenetic silencing in lung cancer. PMID: 24157876
    4. LHX6 is a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis PMID: 23229549
    5. found positive association of LHX6 with Tourette syndrome in some European populations, not others. LHX6 demonstrates a high degree of population differentiation and is correlated with the North to South axis of European genetic variation. PMID: 22435649
    6. hLHX6.1 could be a new tumor suppressor gene in the cervix. PMID: 21240459
    7. Hypermethylation of LHX6 is associated with cervical cancer. PMID: 20428825
    8. differentially methylated hypermethylation of LHX6 is a good cancer marker in HNSCC as well as in other kinds of neoplasias and confirm the importance of searching for markers of epigenetic dysregulation in cancer PMID: 16732332

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 21735

    OMIM: 608215

    KEGG: hsa:26468

    STRING: 9606.ENSP00000377854

    UniGene: Hs.103137