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  4. Recombinant Human LIM/homeobox protein Lhx6 (LHX6)

Recombinant Human LIM/homeobox protein Lhx6 (LHX6)

  • 中文名称：
    人LHX6重组蛋白
  • 货号：
    CSB-YP891795HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LHX6重组蛋白
  • 货号：
    CSB-EP891795HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LHX6重组蛋白
  • 货号：
    CSB-EP891795HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LHX6重组蛋白
  • 货号：
    CSB-BP891795HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LHX6重组蛋白
  • 货号：
    CSB-MP891795HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LHX6
  • Uniprot No.：
  • 别名：
    LHX 6; LHX 6.1; LHX6; LHX6.1; LHX6_HUMAN; LIM homeobox 6; LIM homeobox protein 6; LIM homeodomain protein 6.1; LIM/homeobox protein Lhx6; LIM/homeobox protein Lhx6.1; MGC119542; MGC119544; MGC119545; OTTHUMP00000064113; OTTHUMP00000064114
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-363
  • 氨基酸序列
    MAQPGSGCKA TTRCLEGTAP PAMAQSDAEA LAGALDKDEG QASPCTPSTP SVCSPPSAAS SVPSAGKNIC SSCGLEILDR YLLKVNNLIW HVRCLECSVC RTSLRQQNSC YIKNKEIFCK MDYFSRFGTK CARCGRQIYA SDWVRRARGN AYHLACFACF SCKRQLSTGE EFGLVEEKVL CRIHYDTMIE NLKRAAENGN GLTLEGAVPS EQDSQPKPAK RARTSFTAEQ LQVMQAQFAQ DNNPDAQTLQ KLADMTGLSR RVIQVWFQNC RARHKKHTPQ HPVPPSGAPP SRLPSALSDD IHYTPFSSPE RARMVTLHGY IESQVQCGQV HCRLPYTAPP VHLKADMDGP LSNRGEKVIL FQY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.
  • 基因功能参考文献：
    1. that down-regulation of miR-214 may reverse acquired resistance to erlotinib in NSCLC through mediating its direct target gene LHX6 expression. PMID: 28396596
    2. LHX6 inhibits breast cancer cell proliferation and invasion via repression of the Wnt/beta-catenin signaling pathway. PMID: 26129710
    3. LHX6 is a putative tumour suppressor gene with epigenetic silencing in lung cancer. PMID: 24157876
    4. LHX6 is a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis PMID: 23229549
    5. found positive association of LHX6 with Tourette syndrome in some European populations, not others. LHX6 demonstrates a high degree of population differentiation and is correlated with the North to South axis of European genetic variation. PMID: 22435649
    6. hLHX6.1 could be a new tumor suppressor gene in the cervix. PMID: 21240459
    7. Hypermethylation of LHX6 is associated with cervical cancer. PMID: 20428825
    8. differentially methylated hypermethylation of LHX6 is a good cancer marker in HNSCC as well as in other kinds of neoplasias and confirm the importance of searching for markers of epigenetic dysregulation in cancer PMID: 16732332

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 21735

    OMIM: 608215

    KEGG: hsa:26468

    STRING: 9606.ENSP00000377854

    UniGene: Hs.103137