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KIRREL3 Antibody

  • 货号：
    CSB-PA012372GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8IZU9
  • 基因名：
    KIRREL3
  • 别名：
    KIRREL3 antibody; KIAA1867 antibody; NEPH2 antibody; UNQ5923/PRO4502/PRO19814Kin of IRRE-like protein 3 antibody; Kin of irregular chiasm-like protein 3 antibody; Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human KIRREL3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.
  • 基因功能参考文献：
    1. KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder. PMID: 25902260
    2. Results presented demonstrate for the first time that there are at least 3 splice variants of Kirrel3 expressed in adult human skeletal muscle, two of which have never previously been identified in human muscle. PMID: 25488023
    3. Alterations in KIRREL3 in patients with mild to severe intellectual disability are reported. PMID: 19012874
  • 相关疾病：
    Mental retardation, autosomal dominant 4 (MRD4)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Processed kin of IRRE-like protein 3]: Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Expressed in fetal and adult brain. Also expressed in kidney, specifically in podocytes of kidney glomeruli. Also expressed in skeletal muscle.
  • 数据库链接：

    HGNC: 23204

    OMIM: 607761

    KEGG: hsa:84623

    STRING: 9606.ENSP00000435466

    UniGene: Hs.376015