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  4. Recombinant Human Kin of IRRE-like protein 3 (KIRREL3), partial

Recombinant Human Kin of IRRE-like protein 3 (KIRREL3), partial

  • 货号：
    CSB-YP811640HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP811640HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP811640HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP811640HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP811640HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KIRREL3
  • Uniprot No.：
  • 别名：
    KIRREL3; KIAA1867; NEPH2; UNQ5923/PRO4502/PRO19814Kin of IRRE-like protein 3; Kin of irregular chiasm-like protein 3; Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.
  • 基因功能参考文献：
    1. KIRREL3 interacting proteins MAP1B and MYO16 are potential candidates for intellectual disability and autism spectrum disorder. PMID: 25902260
    2. Results presented demonstrate for the first time that there are at least 3 splice variants of Kirrel3 expressed in adult human skeletal muscle, two of which have never previously been identified in human muscle. PMID: 25488023
    3. Alterations in KIRREL3 in patients with mild to severe intellectual disability are reported. PMID: 19012874
  • 相关疾病：
    Mental retardation, autosomal dominant 4 (MRD4)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Processed kin of IRRE-like protein 3]: Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Expressed in fetal and adult brain. Also expressed in kidney, specifically in podocytes of kidney glomeruli. Also expressed in skeletal muscle.
  • 数据库链接：

    HGNC: 23204

    OMIM: 607761

    KEGG: hsa:84623

    STRING: 9606.ENSP00000435466

    UniGene: Hs.376015