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KCND1 Antibody

  • 货号：
    CSB-PA728154
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA728154(KCND1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA728154(KCND1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: CSB-PA728154(KCND1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q9NSA2
  • 基因名：
    KCND1
  • 别名：
    Kcnd1 antibody; KCND1_HUMAN antibody; Kv4.1 antibody; mShal antibody; OTTHUMP00000025805 antibody; OTTHUMP00000025806 antibody; Potassium voltage gated channel Shal related subfamily member 1 antibody; Potassium voltage gated channel subfamily D member 1 antibody; Potassium voltage-gated channel subfamily D member 1 antibody; Shal type potassium channel antibody; Voltage gated potassium channel Kv4.1 antibody; Voltage gated potassium channel subunit Kv4.1 antibody; Voltage-gated potassium channel subunit Kv4.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human KCND1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
  • 基因功能参考文献：
    1. S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation. PMID: 24675763
    2. reflected in the immunoblotting data KV4.1 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy. PMID: 25003238
    3. These results demonstrated that Kv4.1 plays a role in proliferation of tumorigenic human mammary epithelial cells. PMID: 19401188
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Cell projection, dendrite.
  • 蛋白家族：
    Potassium channel family, D (Shal) (TC 1.A.1.2) subfamily, Kv4.1/KCND1 sub-subfamily
  • 组织特异性：
    Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain.
  • 数据库链接：

    HGNC: 6237

    OMIM: 300281

    KEGG: hsa:3750

    STRING: 9606.ENSP00000218176

    UniGene: Hs.55276