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IRX3 Antibody

  • 货号：
    CSB-PA090661
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using IRX3 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IRX3 Polyclonal antibody
  • Uniprot No.：
    P78415
  • 基因名：
    IRX3
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human IRX3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.
  • 基因功能参考文献：
    1. IRX3 genetic variants associate with birth weight, body mass index and AST/ALT-related transaminase metabolism, supporting the role of IRX3 as an obesity-associated susceptibility gene. PMID: 28316138
    2. Results show that IRX3 deficiency repressed the browning program of white adipocytes partially by regulating UCP1 transcriptional activity. Rare variants of IRX3 were associated with human obesity. PMID: 28988979
    3. Increased adipocyte-specific expression of IRX3 correlates with the presence of the FTO obesity risk haplotype in lean children, whereas it was unaffected by risk variants in obese peers. IRX3 expression in adipocytes was significantly related to adipocyte hypertrophy. PMID: 27560134
    4. Downregulation of miR-377 may contribute to the upregulation of IRX3 in HCC. PMID: 27222047
    5. Strategies to pharmacologically regulate Irx3 function in adult endothelial cells may provide new therapies for angiogenesis. PMID: 25512384
    6. IRX3 function may have a direct functional relationship to both obesity and type 2 diabetes. PMID: 20080751

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/IRO homeobox family
  • 数据库链接：

    HGNC: 14360

    OMIM: 612985

    KEGG: hsa:79191

    STRING: 9606.ENSP00000331608

    UniGene: Hs.499205