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  4. Recombinant Human Iroquois-class homeodomain protein IRX-3 (IRX3)

Recombinant Human Iroquois-class homeodomain protein IRX-3 (IRX3)

  • 中文名称：
    人IRX3重组蛋白
  • 货号：
    CSB-YP011835HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人IRX3重组蛋白
  • 货号：
    CSB-EP011835HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人IRX3重组蛋白
  • 货号：
    CSB-EP011835HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人IRX3重组蛋白
  • 货号：
    CSB-BP011835HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人IRX3重组蛋白
  • 货号：
    CSB-MP011835HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    IRX3
  • Uniprot No.：
  • 别名：
    AI894186; Homeodomain protein IRXB1; Iroquois class homeodomain protein IRX 1; Iroquois homeobox 3; Iroquois homeobox protein 3; Iroquois-class homeodomain protein irx-3; IRX 1; irx3; IRX3_HUMAN; IRXB1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-501
  • 氨基酸序列
    MSFPQLGYQY IRPLYPSERP GAAGGSGGSA GARGGLGAGA SELNASGSLS NVLSSVYGAP YAAAAAAAAA QGYGAFLPYA AELPIFPQLG AQYELKDSPG VQHPAAAAAF PHPHPAFYPY GQYQFGDPSR PKNATRESTS TLKAWLNEHR KNPYPTKGEK IMLAIITKMT LTQVSTWFAN ARRRLKKENK MTWAPRSRTD EEGNAYGSER EEEDEEEDEE DGKRELELEE EELGGEEEDT GGEGLADDDE DEEIDLENLD GAATEPELSL AGAARRDGDL GLGPISDSKN SDSEDSSEGL EDRPLPVLSL APAPPPVAVA SPSLPSPPVS LDPCAPAPAP ASALQKPKIW SLAETATSPD NPRRSPPGAG GSPPGAAVAP SALQLSPAAA AAAAHRLVSA PLGKFPAWTN RPFPGPPPGP RLHPLSLLGS APPHLLGLPG AAGHPAAAAA FARPAEPEGG TDRCSALEVE KKLLKTAFQP VPRRPQNHLD AALVLSALSS S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.
  • 基因功能参考文献：
    1. IRX3 genetic variants associate with birth weight, body mass index and AST/ALT-related transaminase metabolism, supporting the role of IRX3 as an obesity-associated susceptibility gene. PMID: 28316138
    2. Results show that IRX3 deficiency repressed the browning program of white adipocytes partially by regulating UCP1 transcriptional activity. Rare variants of IRX3 were associated with human obesity. PMID: 28988979
    3. Increased adipocyte-specific expression of IRX3 correlates with the presence of the FTO obesity risk haplotype in lean children, whereas it was unaffected by risk variants in obese peers. IRX3 expression in adipocytes was significantly related to adipocyte hypertrophy. PMID: 27560134
    4. Downregulation of miR-377 may contribute to the upregulation of IRX3 in HCC. PMID: 27222047
    5. Strategies to pharmacologically regulate Irx3 function in adult endothelial cells may provide new therapies for angiogenesis. PMID: 25512384
    6. IRX3 function may have a direct functional relationship to both obesity and type 2 diabetes. PMID: 20080751

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/IRO homeobox family
  • 数据库链接：

    HGNC: 14360

    OMIM: 612985

    KEGG: hsa:79191

    STRING: 9606.ENSP00000331608

    UniGene: Hs.499205