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  4. IL5RA Antibody

IL5RA Antibody

  • 货号：
    CSB-PA935849
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA935849(IL5RA Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA935849(IL5RA Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA935849(IL5RA Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q01344
  • 基因名：
  • 别名：
    CD125 antibody; CD125 antigen antibody; CDw125 antibody; HSIL5R3 antibody; IL-5 receptor subunit alpha antibody; IL-5R subunit alpha antibody; IL-5R-alpha antibody; IL-5RA antibody; IL5R antibody; IL5RA antibody; IL5RA_HUMAN antibody; Interleukin 5 Receptor alpha antibody; Interleukin 5 Receptor alpha chain antibody; Interleukin 5 receptor alpha subunit antibody; Interleukin 5 receptor subunit alpha antibody; Interleukin 5 receptor type 3 antibody; Interleukin-5 receptor subunit alpha antibody; MGC26560 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human IL5RA
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    This is the receptor for interleukin-5. The alpha chain binds to IL5.
  • 基因功能参考文献：
    1. Increased activation of B-cells is present following successful Tuberculosis treatment, and the expression of FASLG and IL5RA could potentially be utilized as a signature to monitor treatment response. PMID: 27682872
    2. Interleukin-5Ralpha-targeted treatments offer promises to patients with eosinophilic respiratory disorders; review PMID: 26859368
    3. This is the first study to show significant associations between IL5RA SNP rs17881144, the ATTAGA haplotype, the GTAGCA haplotype, and the GCTGCA haplotype and eczema. PMID: 25523412
    4. This is the first study to show significant associations between IL5RA SNP rs6771148, the ACTAGA haplotype, and the GTAGCA haplotype and the risk of rhinoconjunctivitis. PMID: 24332579
    5. The MDR analysis showed a potential interaction of C1GALT1-330G/T (rs1008898) and IL5RA31+197A/G (rs340833) on the susceptibility of IgAN (P<0.001). Gene-gene interaction may have some influence on the susceptibility to IgA nephropathy. PMID: 23190752
    6. These findings suggest that a functional polymorphism in IL5RA may contribute to eosinophil and mast cell activation along with specific IgE responses to staphylococcal enterotoxin A in aspirin-exacerbated respiratory disease patients. PMID: 23470716
    7. we determined the structure of IL-5 bound to the extracellular domain of IL-5Ralpha. PMID: 22153509
    8. IL-5Ralpha expression on eosinophils inversely correlated with eosinophilia and was significantly elevated in patients with systemic mastocytosis without eosinophilia PMID: 21762978
    9. Study of engineered deglycosylated IL-5 receptor alpha variant proves that unique carbohydrate groups in multiglycosylated receptors can be utilized asymmetrically for function. PMID: 21770429
    10. Polymorphisms in IL5RA, LPL, ITGA2 and NOS3 genes were independently associated with ischemic stroke in Chinese diabetic population. PMID: 21193198
    11. Increased serum level precedes the development of eczema in children PMID: 20735756
    12. findings indicate that retinoids can differentially regulate expression of IL-5Ralpha and that these effects have functional consequences in vitro on eosinophil and basophil differentiation PMID: 11842302
    13. findings are consistent with an airway tissue-selective expression of the IL-5 receptor that mediates IL-5-induced airway hyperresponsiveness independent of eosinophils PMID: 11897983
    14. expression of membrane IL-5Ralpha on bronchoalveolar lavage eosinophils following airway Ag challenge PMID: 12444154
    15. expression of membrane IL-5 receptor alpha on human eosinophils PMID: 12444155
    16. IL-5 receptor expression in cultured human eosinophils is downregulated by its ligand PMID: 12943658
    17. Our findings suggest that polymorphisms in IL5RA might be among the genetic risk factors for asthma development, especially in atopic populations. PMID: 16217591
    18. These data argue that the charged residues of AF17121 are utilized asymmetrically in the pathway of inhibitor-receptor complex formation to deactivate the receptor function PMID: 16430207
    19. These data establish a critical role for JAK kinases and the Ub/proteasome degradation pathway in IL-5R down-regulation. PMID: 17227823
    20. In chronic eosinophilic leukemia, there was a non-significant association between a SNP at rs4054760 and eosinophil count & IL5RA expression. There was no association with FIP1L1-PDGFRA positivity. PMID: 17914408
    21. The genetic association between CCR3 polymorphisms and the number of circulating eosinophils was revealed;it was more pronounced when the CCR3 polymorphisms were paired with polymorphisms in IL5RA. PMID: 17983872
    22. variants of IL5RA and TNFRSF6B may predispose to sporadic IgA nephropathy PMID: 18256354
    23. IL-5-induced effects on betac assembly in the presence of nontagged IL-5Ralpha provide direct evidence that IL-5 can cause higher order rearrangements of betac homo-oligomers PMID: 18326494
    24. IL-5Rs segregate and traffic into two distinct plasma membrane compartments, and establish that IL-5R endocytosis regulates signaling both positively and negatively. PMID: 18511572
    25. The expression of SOL-IL-5Ralpha and TM-IL-5Ralpha differs according to the eosinophil activation state and localization in the body (blood vs tissue) and may therefore be involved in the fine-tuning of the eosinophil homeostasis. PMID: 19170670
    26. Syntenin forms complexes with multiple IL-5Ralpha chains PMID: 19654410

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 5 subfamily
  • 组织特异性：
    Expressed on eosinophils and basophils.
  • 数据库链接：

    HGNC: 6017

    OMIM: 147851

    KEGG: hsa:3568

    STRING: 9606.ENSP00000256452

    UniGene: Hs.68876