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IK Antibody

  • 货号：
    CSB-PA003006
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa cells using IK Polyclonal Antibody
    • Western blot analysis of HELA KB SH-SY5Y 293T 3T3 lysis using IK antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q13123
  • 基因名：
    IK
  • 别名：
    chondrosarcoma associated protein 2 antibody; CSA2 antibody; Cytokine IK antibody; IK antibody; IK cytokine down regulator of HLA II antibody; IK factor antibody; IK Gene antibody; prer protein antibody; Protein Red antibody; Protein RER antibody; RD element antibody; RED protein antibody; RED_HUMAN antibody; RER antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human IK.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species. Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1.; (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.
  • 基因功能参考文献：
    1. IK inhibits Aurora B activation through recruiting PP2A into IK and Aurora B complex. PMID: 26906715
    2. Data suggest an indirect radiosensitivity of hIK channels to low-dose photon irradiation with an impact on cell differentiation. PMID: 25277267
    3. Data suggest that two human spliceosomal factors, RED and SMU1, are recruited to control expression and alternative splicing of viral exportins via PB2 (polymerase PB2) of influenza A virus (H3N2) and are required for efficient viral multiplication. PMID: 24945353
    4. IK is an essential protein for achieving correct mitotic progress through the regulation of mitotic kinases and phosphatases PMID: 24996188
    5. RED is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. PMID: 22351768
    6. IK gene expression is decreased in follicular variant of papillary thyroid carcinoma. PMID: 21509594
    7. At least three genes, orthologous to loci in this LD block, HBEGF, IK, and SRA1, result independently in a phenotype of myocardial contractile dysfunction when their expression is reduced with morpholino antisense reagents. PMID: 19064678

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  • 亚细胞定位：
    Nucleus. Nucleus, nucleoplasm. Chromosome. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族：
    RED family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 5958

    OMIM: 600549

    KEGG: hsa:3550

    STRING: 9606.ENSP00000396301

    UniGene: Hs.421245