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IFRD1 Antibody

  • 货号：
    CSB-PA011069ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: IFRD1 antibody at 1.76μg/ml
      Lane 1: Mouse skeletal muscle tissue
      Lane 2: Hela whole cell lysate
      Lane 3: Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 51, 46 kDa
      Observed band size: 51 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA011069ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA011069ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The recombinant human IFRD1 protein (1-240aa) was used as an immunogen to elicit an immune response in rabbits. Once the immune response was generated, the rabbit serum was collected and subjected to antibody purification using antigen affinity purification.

    The purified rabbit anti-human IFRD1 polyclonal antibody is then characterized by various assays including ELISA, WB, and IHC to confirm its specificity and sensitivity. This IFRD1 antibody can detect human and mouse IFRD1 proteins. The target protein IFRD1 mainly functions to regulate cell growth, differentiation, and apoptosis. It is also involved in various cellular processes, including cell cycle progression, DNA repair, and immune response.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IFRD1 Polyclonal antibody
  • Uniprot No.：
    O00458
  • 基因名：
    IFRD1
  • 别名：
    12 O tetradecanoylphorbol 13 acetate induced sequence 7 antibody; IFRD1 antibody; IFRD1_HUMAN antibody; interferon related developmental regulator 1 antibody; Interferon-related developmental regulator 1 antibody; Nerve growth factor inducible protein PC4 antibody; Nerve growth factor-inducible protein PC4 antibody; PC4 antibody; Pheochromocytoma cell 4 antibody; TIS7 antibody; TPA induced sequence 7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Interferon-related developmental regulator 1 protein (1-240AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal.
  • 基因功能参考文献：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that IFRD1 is a putative marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. High IFRD1 colon cancer expression was significantly associated with decreased 5-year patient survival. PMID: 29094309
    3. this study shows that IFRD1 gene may be associated with pathogenesis of asthma PMID: 27842724
    4. rs7817 polymorphism associated with nasal polyposis in cystic fibrosis patients PMID: 26397160
    5. study reveals an EGFR-IFRD1-mediated viral immune evasion mechanism, which can also be exploited by cancer cells PMID: 26055519
    6. rs5009270 may contribute to hip OA susceptibility by altering proximal femur shape. PMID: 25939412
    7. PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEbeta. PMID: 25308091
    8. Studied the association between IFRD1 polymorphisms and gastric cancer in a Chinese population. PMID: 25073439
    9. IFRD1 expression is systemically up-regulated in CF neutrophils, is linked to the production of ROS, and is modulated by chemokines in CF airway fluids, depending on the IFRD1 genotype. PMID: 23043087
    10. This work provides evidence for the first time of reduced level of IFRD1 protein in murine and human F508del-CFTR airway epithelial cell models. PMID: 21723850
    11. IFRD1 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    12. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in rat as nerve growth factor-inducible immediate early gene (named PC4). PMID: 2467301
    13. IFRD1 is an inducer of skeletal muscle regeneration and of satellite cell amplification, by regulating MyoD and NF-kB. PMID: 21127072
    14. Identification of PC4/IFRD1 as a coactivator of MyoD, a key master gene of muscle development. PMID: 15743821
    15. In the absence of PC4/IFRD1 skeletal muscle differentiation is defective. PMID: 7756174
    16. IFRD1 mRNA decay stress-sensitive regulation is mediated by an upstream open reading frame PMID: 20080976
    17. TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes PMID: 16204248
    18. identification of IFRD1 as a modifier of cystic fibrosis lung disease severity PMID: 19242412
    19. Sequence conservation, animal models, and protein structure evaluation support the involvement of IFRD1 in SMNA PMID: 19409521
    20. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in mouse as TPA-inducible immediate early gene (named Tis7). PMID: 2797820
    21. Identification of the IFRD gene family, comprising the two genes PC4 / Tis7 / IFRD1 and SKMc15 / IFRD2, and in situ-hybridization analysis of their expression during developments PMID: 9722946
    22. PC4/IFRD1 is able to potentiate the transcription of many genes and to inhibit the transcription of few others, thus acting as regulator of transcription, possibly involved in tissue regeneration PMID: 12691737
    23. Functional ablation of PC4/IFRD1 in myoblast cells by sense and antisense strategies as well as by microinjection of PC4/IFRD1 antibodies, inhibits differentiation. PMID: 7756174
    24. PC4/IFRD1, known to be required for muscle differentiation, coactivates MyoD by relieving the HDAC4-mediated inhibition of MEF2C, as a result of its ability to dose-dependently displace HDAC4 from MEF2C. PMID: 15743821
    25. This reference (Tirone and Shooter 1989) shows the cloning and the sequence of the original IFRD1 homolog, isolated in rat as NGF-inducible immediate early gene (named PC4). PMID: 2467301

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  • 蛋白家族：
    IFRD family
  • 组织特异性：
    Expressed in a variety of tissues.
  • 数据库链接：

    HGNC: 5456

    OMIM: 603502

    KEGG: hsa:3475

    STRING: 9606.ENSP00000005558

    UniGene: Hs.744747