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IFRD1 Antibody

  • 货号：
    CSB-PA286863
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA286863(IFRD1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA286863(IFRD1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O00458
  • 基因名：
    IFRD1
  • 别名：
    12 O tetradecanoylphorbol 13 acetate induced sequence 7 antibody; IFRD1 antibody; IFRD1_HUMAN antibody; interferon related developmental regulator 1 antibody; Interferon-related developmental regulator 1 antibody; Nerve growth factor inducible protein PC4 antibody; Nerve growth factor-inducible protein PC4 antibody; PC4 antibody; Pheochromocytoma cell 4 antibody; TIS7 antibody; TPA induced sequence 7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human IFRD1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal.
  • 基因功能参考文献：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that IFRD1 is a putative marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. High IFRD1 colon cancer expression was significantly associated with decreased 5-year patient survival. PMID: 29094309
    3. this study shows that IFRD1 gene may be associated with pathogenesis of asthma PMID: 27842724
    4. rs7817 polymorphism associated with nasal polyposis in cystic fibrosis patients PMID: 26397160
    5. study reveals an EGFR-IFRD1-mediated viral immune evasion mechanism, which can also be exploited by cancer cells PMID: 26055519
    6. rs5009270 may contribute to hip OA susceptibility by altering proximal femur shape. PMID: 25939412
    7. PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEbeta. PMID: 25308091
    8. Studied the association between IFRD1 polymorphisms and gastric cancer in a Chinese population. PMID: 25073439
    9. IFRD1 expression is systemically up-regulated in CF neutrophils, is linked to the production of ROS, and is modulated by chemokines in CF airway fluids, depending on the IFRD1 genotype. PMID: 23043087
    10. This work provides evidence for the first time of reduced level of IFRD1 protein in murine and human F508del-CFTR airway epithelial cell models. PMID: 21723850
    11. IFRD1 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    12. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in rat as nerve growth factor-inducible immediate early gene (named PC4). PMID: 2467301
    13. IFRD1 is an inducer of skeletal muscle regeneration and of satellite cell amplification, by regulating MyoD and NF-kB. PMID: 21127072
    14. Identification of PC4/IFRD1 as a coactivator of MyoD, a key master gene of muscle development. PMID: 15743821
    15. In the absence of PC4/IFRD1 skeletal muscle differentiation is defective. PMID: 7756174
    16. IFRD1 mRNA decay stress-sensitive regulation is mediated by an upstream open reading frame PMID: 20080976
    17. TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes PMID: 16204248
    18. identification of IFRD1 as a modifier of cystic fibrosis lung disease severity PMID: 19242412
    19. Sequence conservation, animal models, and protein structure evaluation support the involvement of IFRD1 in SMNA PMID: 19409521
    20. This reference shows the cloning and the sequence of the original IFRD1 homolog isolated in mouse as TPA-inducible immediate early gene (named Tis7). PMID: 2797820
    21. Identification of the IFRD gene family, comprising the two genes PC4 / Tis7 / IFRD1 and SKMc15 / IFRD2, and in situ-hybridization analysis of their expression during developments PMID: 9722946
    22. PC4/IFRD1 is able to potentiate the transcription of many genes and to inhibit the transcription of few others, thus acting as regulator of transcription, possibly involved in tissue regeneration PMID: 12691737
    23. Functional ablation of PC4/IFRD1 in myoblast cells by sense and antisense strategies as well as by microinjection of PC4/IFRD1 antibodies, inhibits differentiation. PMID: 7756174
    24. PC4/IFRD1, known to be required for muscle differentiation, coactivates MyoD by relieving the HDAC4-mediated inhibition of MEF2C, as a result of its ability to dose-dependently displace HDAC4 from MEF2C. PMID: 15743821
    25. This reference (Tirone and Shooter 1989) shows the cloning and the sequence of the original IFRD1 homolog, isolated in rat as NGF-inducible immediate early gene (named PC4). PMID: 2467301

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  • 蛋白家族：
    IFRD family
  • 组织特异性：
    Expressed in a variety of tissues.
  • 数据库链接：

    HGNC: 5456

    OMIM: 603502

    KEGG: hsa:3475

    STRING: 9606.ENSP00000005558

    UniGene: Hs.744747