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IFIT5 Antibody

  • 货号：
    CSB-PA008475
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q13325
  • 基因名：
    IFIT5
  • 别名：
    FLJ53857 antibody; FLJ92678 antibody; IFIT-5 antibody; IFIT5 antibody; IFIT5_HUMAN antibody; Interferon induced protein with tetratricopeptide repeats 5 antibody; Interferon-induced protein with tetratricopeptide repeats 5 antibody; Retinoic acid and interferon inducible 58 kDa protein antibody; Retinoic acid and interferon inducible protein (58kD) antibody; Retinoic acid- and interferon-inducible 58 kDa protein antibody; RI58 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human IFIT-5.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments. Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and selectively binds AT-rich dsDNA. Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7.
  • 基因功能参考文献：
    1. IFIT5 promotes SeV-induced IKK phosphorylation and NF-kappaB activation by regulating the recruitment of IKK to TAK1. PMID: 26334375
    2. show that IFIT5 binds precursor and processed tRNAs, as well as other RNA polymerase III transcripts. Our findings establish the RNA recognition specificity of the human innate immune response protein IFIT5 PMID: 25092312
    3. TRIF-N-terminal helical domain shares structural similarity with IFIT5. PMID: 24311583
    4. IFIT5 consists of 24 alpha-helices that pack into a special "V"-like structure. PMID: 23774268
    5. IFIT5 recognizes cellular RNA instead of protein partners. PMID: 23317505
    6. crystal structures of human IFIT5, its complex with PPP-RNAs, and an amino-terminal fragment of IFIT1 PMID: 23334420

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  • 亚细胞定位：
    Cell projection, ruffle membrane. Note=Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.
  • 蛋白家族：
    IFIT family
  • 数据库链接：

    HGNC: 13328

    OMIM: 616135

    KEGG: hsa:24138

    STRING: 9606.ENSP00000360860

    UniGene: Hs.252839