Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. IFIT5 Antibody

IFIT5 Antibody

  • 货号：
    CSB-PA011023LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: IFIT5 antibody at 2µg/ml
      Lane 1: A375 whole cell lysate
      Lane 2: Jurkat whole cell lysate
      Lane 3: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 56, 51 kDa
      Observed band size: 56 kDa
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA011023LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA011023LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IFIT5 Polyclonal antibody
  • Uniprot No.：
    Q13325
  • 基因名：
    IFIT5
  • 别名：
    FLJ53857 antibody; FLJ92678 antibody; IFIT-5 antibody; IFIT5 antibody; IFIT5_HUMAN antibody; Interferon induced protein with tetratricopeptide repeats 5 antibody; Interferon-induced protein with tetratricopeptide repeats 5 antibody; Retinoic acid and interferon inducible 58 kDa protein antibody; Retinoic acid and interferon inducible protein (58kD) antibody; Retinoic acid- and interferon-inducible 58 kDa protein antibody; RI58 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Interferon-induced protein with tetratricopeptide repeats 5 protein (107-320AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，IFIT5 Antibody (CSB-PA011023LA01HU)，的标记方式是Non-conjugated。对于IFIT5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA011023LB01HU IFIT5 Antibody, HRP conjugated ELISA
    FITC CSB-PA011023LC01HU IFIT5 Antibody, FITC conjugated
    Biotin CSB-PA011023LD01HU IFIT5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments. Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and selectively binds AT-rich dsDNA. Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7.
  • 基因功能参考文献：
    1. IFIT5 promotes SeV-induced IKK phosphorylation and NF-kappaB activation by regulating the recruitment of IKK to TAK1. PMID: 26334375
    2. show that IFIT5 binds precursor and processed tRNAs, as well as other RNA polymerase III transcripts. Our findings establish the RNA recognition specificity of the human innate immune response protein IFIT5 PMID: 25092312
    3. TRIF-N-terminal helical domain shares structural similarity with IFIT5. PMID: 24311583
    4. IFIT5 consists of 24 alpha-helices that pack into a special "V"-like structure. PMID: 23774268
    5. IFIT5 recognizes cellular RNA instead of protein partners. PMID: 23317505
    6. crystal structures of human IFIT5, its complex with PPP-RNAs, and an amino-terminal fragment of IFIT1 PMID: 23334420

    显示更多

    收起更多

  • 亚细胞定位：
    Cell projection, ruffle membrane. Note=Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.
  • 蛋白家族：
    IFIT family
  • 数据库链接：

    HGNC: 13328

    OMIM: 616135

    KEGG: hsa:24138

    STRING: 9606.ENSP00000360860

    UniGene: Hs.252839