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ICMT Antibody

  • 货号：
    CSB-PA010956GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O60725
  • 基因名：
    ICMT
  • 别名：
    1700008E11Rik antibody; C80758 antibody; fcmt antibody; Gm13095 antibody; HSTE14 antibody; Icmt antibody; ICMT_HUMAN antibody; Isoprenylcysteine carboxylmethyltransferase antibody; MGC118506 antibody; MGC39955 antibody; MGC95322 antibody; MST098 antibody; MSTP098 antibody; OTTMUSG00000010406 antibody; pcCMT antibody; PCMT antibody; PPMT antibody; Prenylated protein carboxyl methyltransferase antibody; Prenylcysteine carboxyl methyltransferase antibody; Protein-S-isoprenylcysteine O-methyltransferase antibody; RP23-421E12.4 antibody; STE14 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ICMT
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
  • 基因功能参考文献：
    1. Using cell culturing system, mouse model and patient samples, this work is the first to demonstrate the essential roles of Icmt in ovarian cancer via Ras signaling, particularly on its response to chemotherapy. PMID: 29746868
    2. Apoptosis, but not autophagy, that is induced via p21-activated BNIP3 expression accounts for the efficacy of ICMT inhibition in sensitive pancreatic cancer cells in both in vitro and in vivo models. In contrast, cells resistant to ICMT inhibition demonstrated no mitochondria dysfunction or p21 signaling changes under ICMT suppression PMID: 28167504
    3. ICMT catalyzed carboxylmethylation is critical for RAB4A activation and interaction with effectors, its localization to endosomes and recycling vesicles, and hence important for RAB4A-dependent integrin beta3 recycling to plasma membrane. PMID: 28604748
    4. ICMT function is critical for the tumorigenesis capacity of naturally occurring mutant KRAS human cancer cells. PMID: 28192404
    5. simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML. PMID: 26706195
    6. impact of Icmt on tumorigenic processes PMID: 25151967
    7. Silencing ICMT in osteosarcoma cells decreased Notch1 signaling in response to stimulation with cell-surface ligands. PMID: 24216479
    8. a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion. PMID: 20798596
    9. modulation of pcCMT activity in retinoic acid (RA)-treated SH-SY5Y neuroblastoma cells PMID: 11906819
    10. ICMTase is a critical component of the redox-sensitive VCAM-1-selective signaling pathway and appears to activate a discrete inflammatory signaling pathway, at least in part, through the methylation of Rac1 in endothelial cells. PMID: 12006387
    11. findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase methylation and activation and its downstream antiapoptotic signaling pathway. PMID: 12631708
    12. These studies identify isoprenylcysteine carboxyl methyltransferase as a potential target for reducing the growth of K-Ras- and B-Raf-induced malignancies. PMID: 14966563
    13. ICMT inhibition induces endothelial cell apoptosis through GRP94 PMID: 17347446
    14. Icmt traverses the Eendoplasmic reticulum membrane eight times, with both N and C termini disposed toward the cytosol and with a helix-turn-helix structure comprising transmembrane (TM) segments 7 and 8. PMID: 19158273
    15. Inhibition of isoprenylcysteine carboxylmethyltransferase (Icmt) decreases activation of RhoA and Rac1, and in the absence of Icmt activity, addition of exogenous RhoA or Rac1 partially rescues directed and random migration, respectively. PMID: 19651782

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Class VI-like SAM-binding methyltransferase superfamily, Isoprenylcysteine carboxyl methyltransferase family
  • 组织特异性：
    Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.
  • 数据库链接：

    HGNC: 5350

    OMIM: 605851

    KEGG: hsa:23463

    STRING: 9606.ENSP00000343552

    UniGene: Hs.515688