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HAP1 Antibody

  • 货号：
    CSB-PA010129LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of SH-SY5Y cells with CSB-PA010129LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HAP1 Polyclonal antibody
  • Uniprot No.：
    P54257
  • 基因名：
    HAP1
  • 别名：
    HAP 1 antibody; HAP 1A antibody; HAP 2 antibody; HAP-1 antibody; Hap1 antibody; HAP1_HUMAN antibody; HAP2 antibody; HAPP antibody; hHAP1 antibody; hHLP1 antibody; HIP 5 antibody; HIP5 antibody; HLP antibody; HLP1 antibody; Huntingtin associated protein 1A antibody; Huntingtin-associated protein 1 antibody; huntingtin-associated protein 2 antibody; Neuroan 1 antibody; Neuroan1 antibody; OTTHUMP00000164746 antibody; OTTHUMP00000164747 antibody; OTTHUMP00000232821 antibody; OTTHUMP00000232822 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Huntingtin-associated protein 1 protein (328-580AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HAP1 Antibody (CSB-PA010129LA01HU)，的标记方式是Non-conjugated。对于HAP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010129LB01HU HAP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA010129LC01HU HAP1 Antibody, FITC conjugated
    Biotin CSB-PA010129LD01HU HAP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).
  • 基因功能参考文献：
    1. HAP1 is expressed in endocrine cells of the human gut. PMID: 27737633
    2. data fully support that HAP1 is a GKAP, anchoring specifically to the cGMP-dependent protein kinase isoform Ibeta, and provide further evidence that also PKG spatiotemporal signaling is largely controlled by anchoring proteins PMID: 25653285
    3. The -141 T > G polymorphism, but not the 1349 T > G polymorphism, may have protective effects for lung cancer. PMID: 25081373
    4. HAP1 gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity PMID: 25446120
    5. Overexpression of HAP1 reduced in vitro cell growth in breast cancer cell lines. PMID: 23440330
    6. The results of this study found no association was found between the HAP1 T441M polymorphism and the age at onset of Huntington's disease . PMID: 22698993
    7. The results of this study suggested that HAP1 co-localizes and associates with APP in physiological conditions of mouse and human brain. PMID: 22731248
    8. WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1). PMID: 21985783
    9. HAP1/stigmoid body interacts with the normal ataxin-3 through Josephin domain PMID: 21386698
    10. sortilin stabilizes the proBDNF.HAP1 complex PMID: 21357693
    11. ADORA2A, but not HAP1 or OGG1, may have a role in age at onset in Huntington's disease PMID: 20512606
    12. REVIEW: function of HAP1 PMID: 19262167
    13. HAP1 may participate in axonal transport and activity-dependent release of pro-BDNF by interacting with the BDNF prodomain. PMID: 19996106
    14. The combination of siRNA, the SB transposon, and an accurate transgenic mouse model may permit evaluation of this approach in preventing the pathogenesis associated with expression of mutant Htt. PMID: 15737634
    15. Study provides genetic and functional evidence that the M441-HAP1 polymorphism modifies the age-at-onset of Huntington's disease . PMID: 18192679
    16. REST/NRSF, dynactin p150(Glued), huntingtin, HAP1, and RILP form a complex involved in the translocation of REST/NRSF into the nucleus and HAP1 controls REST/NRSF cellular localization in neurons PMID: 18922795

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  • 亚细胞定位：
    Cytoplasm. Cell projection, axon. Cell junction, synapse, presynapse. Cytoplasm, cytoskeleton. Cell projection, dendritic spine. Cell projection, dendrite. Lysosome. Endoplasmic reticulum. Mitochondrion. Nucleus. Cytoplasmic vesicle, autophagosome. Early endosome. Cell projection, growth cone. Cell projection, neuron projection. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
  • 组织特异性：
    Predominantly expressed in brain. Selectively expressed in neurons.
  • 数据库链接：

    HGNC: 4812

    OMIM: 600947

    KEGG: hsa:9001

    UniGene: Hs.158300