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GZMM Antibody

  • 货号：
    CSB-PA803254
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100
    • Immunohistochemical analysis of paraffin-embedded Human-lymph, antibody was diluted at 1:100
    • Immunohistochemical analysis of paraffin-embedded Human-lymph, antibody was diluted at 1:100
  • 其他：

产品详情

  • Uniprot No.：
    P51124
  • 基因名：
    GZMM
  • 别名：
    GRAM_HUMAN antibody; Granzyme M (lymphocyte met ase 1) antibody; Granzyme M antibody; GranzymeM antibody; GZM M antibody; Gzmm antibody; HU Met 1 antibody; HU-Met-1 antibody; LMET 1 antibody; LMET1 antibody; Lymphocyte met ase 1 antibody; MET 1 antibody; Met 1 serine protease antibody; Met ase antibody; Met-1 serine protease antibody; Met-ase antibody; MET1 antibody; Met1 serine protease antibody; Natural killer cell granular protease antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 207-256
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
  • 基因功能参考文献：
    1. GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced. PMID: 27441655
    2. We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain. PMID: 27133719
    3. Granzym M may be important in regulating HCMV latency and reactivation in SCT patients. PMID: 24316590
    4. GrM is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K in the presence of RNA. PMID: 23099853
    5. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. PMID: 21979465
    6. Results indicate that cellular overexpression of SERPINB4 inhibits recombinant GrM-induced as well as NK cell-mediated cell death. PMID: 21857942
    7. Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes. PMID: 20107908
    8. Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71. PMID: 21059895
    9. survivin cleavage by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells PMID: 20406824
    10. These findings support not only a role for GrM in the innate but also in the adaptive immune response. PMID: 19896187
    11. GM expression is a distinctive feature of the nasal NK/T-cell, gamma delta T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity. PMID: 12506019
    12. granzyme M represents a third major and specialized perforin-dependent cell death pathway that plays a significant role in death mediated by NK cells PMID: 15028722
    13. Granzyme (Gzm)M can directly degrade inhibitor of caspase-activated DNase (ICAD) to activate CAD, leading to DNA damage; GzmM cleaves DNA damage sensor enzyme poly(ADP-ribose) polymerase to prevent cellular DNA repair and force apoptosis. PMID: 16818775
    14. Granzyme M targets major components of the cytoskeleton that likely contribute to natural killer (NK) cell-induced cell death. PMID: 18523284
    15. NPM is essential for cell viability, these data suggest that targeting of NPM by granzyme M may contribute to tumor cell eradication by abolishing NPM function. PMID: 19103589
    16. Structure-based mutagenesis reveals that the amino-terminus and catalytic triad of GzmM are most essential for proteolytic function. PMID: 19542453

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  • 亚细胞定位：
    Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes.
  • 蛋白家族：
    Peptidase S1 family, Granzyme subfamily
  • 组织特异性：
    Highly and constitutively expressed in activated natural killer (NK) cells.
  • 数据库链接：

    HGNC: 4712

    OMIM: 600311

    KEGG: hsa:3004

    STRING: 9606.ENSP00000264553

    UniGene: Hs.465511