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GTF2A1 Antibody

  • 货号：
    CSB-PA009040
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P52655
  • 基因名：
    GTF2A1
  • 别名：
    General transcription factor IIA 1 19/37kDa antibody; General transcription factor IIA subunit 1 antibody; General transcription factor IIA1 antibody; Glucose regulated protein 58kD pseudogene antibody; gtf2a1 antibody; TF2A1 antibody; TF2AA_HUMAN antibody; TFIIA 42 antibody; TFIIA alpha p55 antibody; TFIIA alpha p55, isoform 1 antibody; TFIIA p19 subunit antibody; TFIIA p35 subunit antibody; TFIIA-42 antibody; TFIIAL antibody; Transcription initiation factor IIA beta chain antibody; Transcription initiation factor IIA subunit 1 antibody; Transcription initiation factor TFIIA 42 kDa subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human TFIIA-α.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.
  • 基因功能参考文献：
    1. In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR) pathway with the genes MED1, HSPA1L, GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations. PMID: 28291257
    2. Data suggest that many TATA-box-containing promoters contain a TFIIA recognition element (IIARE) that activates transcription by increasing the recruitment of RNA polymerase II, TFIIA (TF2A1/TF2A2 subunits), TAF4, and P300. (TAF4 = TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1; P300 = E1A binding protein p300) PMID: 28539359
    3. The interaction of TBP-like protein with TFIIA is essential to suppress proteasome-dependent turnover of TBP-like protein PMID: 27696626
    4. Our results provide first evidence that Taspase1 processing affects TFIIA regulation of TFIID and suggest that Taspase1 processing of TFIIA is required to establish INR-selective core promoter activity in the presence of NC2. PMID: 25996597
    5. spatial positioning of the DNA-bound activation domain is important for efficient activation, possibly by maximizing its interactions with the transcriptional machinery including the TBP-TFIIA-TFIIB-promoter quaternary complex PMID: 12538582
    6. Results present the X-ray structures of human and yeast TATA box-binding protein /transcription factor IIA/DNA complexes at 2.1A and 1.9A resolution, respectively PMID: 12972251
    7. transcription factor IIA may regulate the intracellular molecular state and the function of TATA-binding protein-like protein (TLP) through its property of binding to TLP PMID: 14570910
    8. Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo. PMID: 16537915
    9. TFIIA induces a conformational change within the TBP/TATA complex that enhances its stability under both in vitro and physiological salt conditions. PMID: 17681538
    10. GTF2A1 alone, or GTF2A1 plus HAAO are excellent candidate biomarkers for detecting Ovarian cancer PMID: 19724865
    11. V96F substitution of a deamidated human GTF2A1 (TFIIA) peptide promotes T-cell activation in an in vitro model of Celiac disease inflammation. PMID: 12054857

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TFIIA subunit 1 family
  • 数据库链接：

    HGNC: 4646

    OMIM: 600520

    KEGG: hsa:2957

    STRING: 9606.ENSP00000452454

    UniGene: Hs.592334