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  4. GRB10 Antibody

GRB10 Antibody

  • 货号：
    CSB-PA358941
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA358941(GRB10 Antibody) at dilution 1/12, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q13322
  • 基因名：
  • 别名：
    grb 10 antibody; GRB IR antibody; grb-10 antibody; GRB10 adapter protein antibody; GRB10 adaptor protein antibody; GRB10 antibody; GRB10_HUMAN antibody; GRBIR antibody; Growth factor receptor bound protein 10 antibody; Growth factor receptor-bound protein 10 antibody; Insulin receptor binding protein antibody; Insulin receptor binding protein GRB IR antibody; Insulin receptor-binding protein Grb-IR antibody; IRBP antibody; KIAA0207 antibody; Maternally expressed gene 1 antibody; MEG1 antibody; RSS antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human GRB10
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:10-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine p...显示更多
  • 基因功能参考文献：
    1. Through syngeneic comparison, our study identifies for the first time that Grb10 is associated with the pluripotency state in nuclear transfer embryonic stem cells. PMID: 28476045
    2. Data suggest that GRB10 and GRB14 are both Ca2+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 and GRB14, as compared to a single one present in GRB7. (GRB10 = growth factor receptor-bound protein 10; GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 = growth factor receptor-bound protein 7) PMID: 28295264
    3. GRB10 may regulate degradation of the IL-4 receptor-signaling complex through interactions with NEDD4.2. PMID: 27742835
    4. placental expression associated positively with placental weight, birth weight, and neonatal head circumference PMID: 26390806
    5. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 PMID: 27049325
    6. This study demonstrated that the most significant SNP (rs11770199; p = 0.0003) in single-site analysis was located on chromosome 7 in the GRB10 gene. PMID: 25391383
    7. Association of the intronic polymorphism rs12540874 A>G of the GRB10 gene with high birth weight. PMID: 25103788
    8. Tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism. PMID: 24699409
    9. Studies indicate that insulin receptor (IR) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10/14 and SH2B1/B2 adaptors. PMID: 23190452
    10. H19 and GRB10 methylation was normal in Albright's hereditary osteodystrophy patients. PMID: 22679513
    11. discovery of Grb10 as an mTORC1 substrate PMID: 21659604
    12. Grb10 interacts with Bim L and inhibits its proapoptotic activity in a phosphorylation-dependant manner. PMID: 20174874
    13. GRB10 gene is expressed from the paternal allele in the brain, but from the maternal allele in the placental trophoblasts. PMID: 19487367
    14. role in inhibiting insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor PMID: 12493740
    15. The structure of this protein's SH domains affect ligand specificity. PMID: 12551896
    16. Grb10 acts as a positive regulator in VEGF-R2 signaling and protects VEGF-R2 from degradation by interacting with Nedd4, a component of the endocytic machinery PMID: 15060076
    17. GRB10 protein products are correlated with parameters of birth size. PMID: 15506681
    18. there is a phosphorylation-regulated complex formation of Grb10 with 14-3-3 and Akt PMID: 15722337
    19. Up-regulation of growth factor receptor-bound protein 10 is associated with cervical squamous cell carcinoma PMID: 15870923
    20. Ser(150) and Ser(476) of human Grb10zeta are phosphorylated in intact cells. PMID: 15952796
    21. Together, our results suggest that, in addition to inhibiting IR kinase activity by directly binding to the IR, Grb10 also negatively regulates insulin signaling by mediating insulin-stimulated degradation of the receptor. PMID: 16434550
    22. Single nucleotide polymorphism is associated with type 2 diabetes among Whites. PMID: 16644667
    23. GRB10 is a novel negative regulator of the Wnt signaling pathway. The finding that GRB10 interferes with the binding of Axin to LRP6 indicated a possible molecular mechanism by which the overexpression of GRB10 suppresses Wnt signaling. PMID: 17376403
    24. Binds to the Raf-1 and MEK1 kinases. Potential role in the regulation of apoptosis. PMID: 9553107
    25. Role in the regulation of mitogenesis by receptor tyrosine kinases. PMID: 10454568
    26. Mostly localized to the mitochondria. Can relocalize to the plasma membrane and lamellipodia under certain conditions. PMID: 10585452

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    GRB7/10/14 family
  • 组织特异性：
    Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.
  • 数据库链接：

    HGNC: 4564

    OMIM: 601523

    KEGG: hsa:2887

    STRING: 9606.ENSP00000381793

    UniGene: Hs.164060