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GPSM3 Antibody

  • 货号：
    CSB-PA896517LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA896517LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GPSM3 Polyclonal antibody
  • Uniprot No.：
    Q9Y4H4
  • 基因名：
    GPSM3
  • 别名：
    Activator of G-protein signaling 4 antibody; AGS4 antibody; C6orf9 antibody; G protein signalling modulator 3 (AGS3 like; C. elegans) antibody; G-protein signaling modulator 3 (AGS3-like; C. elegans) antibody; G-protein-signaling modulator 3 antibody; G18 antibody; G18.1a antibody; G18.1b antibody; G18.2 antibody; Gpsm3 antibody; GPSM3_HUMAN antibody; NG1 antibody; OTTHUMP00000029351 antibody; Protein G18 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human G-protein-signaling modulator 3 protein (1-160AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GPSM3 Antibody (CSB-PA896517LA01HU)，的标记方式是Non-conjugated。对于GPSM3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA896517LB01HU GPSM3 Antibody, HRP conjugated ELISA
    FITC CSB-PA896517LC01HU GPSM3 Antibody, FITC conjugated
    Biotin CSB-PA896517LD01HU GPSM3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.
  • 基因功能参考文献：
    1. role for GPSM3 in neutrophil migration toward proinflammatory chemoattractants LTB4 and CXCL8-a discovery that helps strengthen the association between the promoter-weakening GPSM3 SNP rs204989 and a reduced risk of rheumatoid arthritis PMID: 27307211
    2. Genetic variations in GPSM3 which are associated with protection from rheumatoid arthritis affect its transcript abundance. PMID: 26821282
    3. findings suggest that GPSM3 acts as a direct negative regulator of NLRP3 function. PMID: 25271165
    4. Phosphorylation of GPSM3 by a proline-directed serine/threonine kinase and the resultant association of 14-3-3 is the first description of post-translational regulation of GPSM3 subcellular localization PMID: 22843681
    5. GPSM3 increases Gbeta stability until formation of the Gbetagamma dimer, including association of the Gbeta-GPSM3 complex with phosducin-like protein PhLP and T-complex protein 1 subunit eta (CCT7), two known chaperones of neosynthesized Gbeta subunits. PMID: 22167191
    6. AGS4-Galpha(i) complexes directly couple to a G-protein-coupled receptor and may serve as substrates for agonist-induced G-protein activation. PMID: 20452976
    7. Mutational analysis of the role of GoLoco motifs in guanine nucleotide dissociation inhibitor activity of G18 protein. PMID: 14656218

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Expressed in heart, placenta, lung and liver.
  • 数据库链接：

    HGNC: 13945

    KEGG: hsa:63940

    STRING: 9606.ENSP00000364180

    UniGene: Hs.520046