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  4. Recombinant Human G-protein-signaling modulator 3 (GPSM3)

Recombinant Human G-protein-signaling modulator 3 (GPSM3)

  • 中文名称：
    人GPSM3重组蛋白
  • 货号：
    CSB-YP896517HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GPSM3重组蛋白
  • 货号：
    CSB-EP896517HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GPSM3重组蛋白
  • 货号：
    CSB-EP896517HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GPSM3重组蛋白
  • 货号：
    CSB-BP896517HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GPSM3重组蛋白
  • 货号：
    CSB-MP896517HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GPSM3
  • Uniprot No.：
  • 别名：
    Activator of G-protein signaling 4; AGS4; C6orf9; G protein signalling modulator 3 (AGS3 like; C. elegans); G-protein signaling modulator 3 (AGS3-like; C. elegans); G-protein-signaling modulator 3; G18; G18.1a; G18.1b; G18.2; Gpsm3; GPSM3_HUMAN; NG1; OTTHUMP00000029351; Protein G18
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-160
  • 氨基酸序列
    MEAERPQEEE DGEQGPPQDE EGWPPPNSTT RPWRSAPPSP PPPGTRHTAL GPRSASLLSL QTELLLDLVA EAQSRRLEEQ RATFYTPQNP SSLAPAPLRP LEDREQLYST ILSHQCQRME AQRSEPPLPP GGQELLELLL RVQGGGRMEE QRSRPPTHTC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.
  • 基因功能参考文献：
    1. role for GPSM3 in neutrophil migration toward proinflammatory chemoattractants LTB4 and CXCL8-a discovery that helps strengthen the association between the promoter-weakening GPSM3 SNP rs204989 and a reduced risk of rheumatoid arthritis PMID: 27307211
    2. Genetic variations in GPSM3 which are associated with protection from rheumatoid arthritis affect its transcript abundance. PMID: 26821282
    3. findings suggest that GPSM3 acts as a direct negative regulator of NLRP3 function. PMID: 25271165
    4. Phosphorylation of GPSM3 by a proline-directed serine/threonine kinase and the resultant association of 14-3-3 is the first description of post-translational regulation of GPSM3 subcellular localization PMID: 22843681
    5. GPSM3 increases Gbeta stability until formation of the Gbetagamma dimer, including association of the Gbeta-GPSM3 complex with phosducin-like protein PhLP and T-complex protein 1 subunit eta (CCT7), two known chaperones of neosynthesized Gbeta subunits. PMID: 22167191
    6. AGS4-Galpha(i) complexes directly couple to a G-protein-coupled receptor and may serve as substrates for agonist-induced G-protein activation. PMID: 20452976
    7. Mutational analysis of the role of GoLoco motifs in guanine nucleotide dissociation inhibitor activity of G18 protein. PMID: 14656218

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Expressed in heart, placenta, lung and liver.
  • 数据库链接：

    HGNC: 13945

    KEGG: hsa:63940

    STRING: 9606.ENSP00000364180

    UniGene: Hs.520046