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  4. GOPC Antibody

GOPC Antibody

  • 货号：
    CSB-PA009673GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9HD26
  • 基因名：
    GOPC
  • 别名：
    CAL antibody; CFTR associated ligand antibody; CFTR-associated ligand antibody; dJ94G16.2 antibody; dJ94G16.2 PIST antibody; FIG antibody; Fused in glioblastoma antibody; Golgi associated PDZ and coiled coil motif containing antibody; Golgi associated PDZ and coiled coil motif containing protein antibody; Golgi-associated PDZ and coiled-coil motif-containing protein antibody; GOPC 1 antibody; GOPC antibody; GOPC_HUMAN antibody; GOPC1 antibody; OTTHUMP00000040403 antibody; PDZ protein interacting specifically with TC 10 antibody; PDZ protein interacting specifically with TC10 antibody; PDZ/coiled coil domain binding partner for the rho family GTPase TC 10 antibody; PDZ/coiled coil domain binding partner for the rho family GTPase TC10 antibody; PIST antibody; Protein interacting specifically with Tc 10 antibody; Protein interacting specifically with Tc10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GOPC
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.
  • 基因功能参考文献：
    1. PIST, a Golgi-associated PDZ domain-containing protein, interacts with PCDH15 in the plasma membrane. PMID: 27867666
    2. CAL can regulate the anterograde trafficking, the internalization as well as the signaling of CRFR1 via modulating the post-translational modifications that the receptor undergoes at the Golgi apparatus. PMID: 26115868
    3. CAL overexpression retards B2AR expression in Golgi apparatus and reduces the receptor expression in the plasma membrane. PMID: 25876703
    4. Six out of 65 (9%) BTC patients were positive for the FIG-ROS1 fusion, comprising two out of 14 (14%) gallbladder carcinoma (GBC) patients and four out of 25 (16%) extrahepatic cholangiocarcinoma (ECC) patients. PMID: 25231053
    5. Our data suggest that PIST contributes to the fine-tuning of b1AR sorting both during biosynthetic and postendocytic trafficking PMID: 25614626
    6. None of 268 gliomas analysed showed the FIG-ROS1(L) rearrangement. PMID: 24999209
    7. Stereochemical preferences modulate affinity and selectivity among CAL PDZ domain protein variants that bind CFTR. PMID: 24210758
    8. FIG-ROS fusion protein, which is found in a subset of intrahepatic cholangiocarcinoma patients, accelerates cholangiocarcinogenesis. PMID: 24154728
    9. Data indicate that E3 ubiquitin ligase MARCH2 co-immunoprecipitated and co-localized with CAL and syntaxin 6 (STX6), and show the ubiquitination of CFTR by MARCH2. PMID: 23818989
    10. The coiled-coil domain of PIST was then purified to homogeneity and crystallized at 293 K. Finally, X-ray diffraction data were collected to a resolution of 4.0 A from a crystal belonging to the hexagonal space group P6(2)22 or P6(4)22. PMID: 23545662
    11. crystals of CAL PDZ domain diffracted to 1.4 A resolution PMID: 21543871
    12. establish CAL inhibitors as founding members of a class of CFTR "stabilizers" specifically designed to reduce DeltaF508-CFTR post-endocytic breakdown PMID: 21105033
    13. Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator PMID: 20130090
    14. The FIG-ROS locus encodes for an in-frame fusion protein with a constitutively active kinase activity, suggesting that FIG-ROS may act as an oncogene. PMID: 12661006
    15. CAL retains CFTR in the cell and targets CFTR for degradation. PMID: 14570915
    16. modulates beta1AR intracellular trafficking PMID: 15358775
    17. golgin-160 assosiates in an isoform-specific manner with the Golgi-associated protein PIST PMID: 15951434
    18. intracellular sorting of the somatostatin receptor subtype 5 is regulated by interactions with PDZ domain proteins PIST/GOPC and PDZK1 PMID: 16012170
    19. Our discoveries provide insight into the specific interaction of the GOPC PDZ domain with the C-terminal peptide of Nlg and also provide a general insight about the possible binding mode of the interaction of Nlg with other PDZ domain-containing proteins. PMID: 16882988
    20. CAL is a negative regulator of DeltaF508-CFTR cell-surface expression PMID: 17158866
    21. The cystic fibrosis-associated ligand (CAL) PDZ domain of the C-terminus of cystic fibrosis-associated conductance regulator (CFTR) is competitively involved with PDZ proteins Na+/H+ exchanger-3 regulatory factors NHERF1 and NHERF2. PMID: 18754678

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  • 相关疾病：
    A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
  • 亚细胞定位：
    Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Cell projection, dendrite.
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 17643

    OMIM: 606845

    KEGG: hsa:57120

    STRING: 9606.ENSP00000357484

    UniGene: Hs.191539