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GNAI2 Antibody

  • 货号：
    CSB-PA009589GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P04899
  • 基因名：
  • 别名：
    Adenylate cyclase inhibiting G alpha protein antibody; Adenylate cyclase-inhibiting G alpha protein antibody; GIP antibody; GNAI 2 antibody; Gnai2 antibody; GNAI2_HUMAN antibody; GNAI2B antibody; GTP binding regulatory protein Gi alpha 2 chain antibody; Guanine nucleotide binding protein G protein alpha inhibiting activity polypeptide 2 antibody; Guanine nucleotide-binding protein G(i) subunit alpha-2 antibody; H LUCA15.1 antibody; H LUCA16.1 antibody; WUGSC:H LUCA15.1 antibody; WUGSC:H LUCA16.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Human GNAI2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF, IP
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.; Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.
  • 基因功能参考文献：
    1. The data show that the nonpalmitoylated CB1 receptor significantly reduced its association with Galphai2 . PMID: 28722168
    2. MicroRNA-222-3p/GNAI2/AKT signaling axis inhibits epithelial ovarian cancer cell growth and is associated with good overall survival. PMID: 27811362
    3. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing. PMID: 26662512
    4. Data strongly implicate GNAI2 as a critical regulator of oncogenesis and an upstream driver of cancer progression in ovarian carcinoma. PMID: 24423449
    5. Galpha(i2) activates the TRPC4 channel by direct binding. PMID: 25788576
    6. Changes in ion selectivity and pore dilation of the TRPC4 channel elicited by the Galphai2 subunit, were studied. PMID: 24011658
    7. Galphai2(Q205L) regulates satellite cell differentiation into myotubes in a protein kinase C - and histone deacetylase -dependent manner PMID: 24298018
    8. There is an interaction between the activated Gsalpha subunit and membrane lipid microdomains in the pathophysiology of some major depressive disorders. PMID: 23490066
    9. These results suggest that the extent of G-protein-mediated inhibition is significantly reduced in the K1336E mutant CaV2.1 Ca(2+) channels PMID: 23430985
    10. The ubiquitination of Galphai2 and Galphaq is suppressed by expression of Ric-8A. The suppression likely requires Ric-8A interaction with these Galpha proteins; the C-terminal truncation of Galphaq and Galphai2 completely abrogates their interaction with Ric-8A. PMID: 23665327
    11. Gialpha2 plays an essential role in OXT and EGF signaling to induce prostate cancer cell migration. PMID: 22936789
    12. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Galpha(i2) for degradation through ubiquitination PMID: 23071112
    13. Galphai2 as a novel claudin-5 partner required for TJ integrity in brain endothelial cells. PMID: 22333621
    14. Suggest that Gnia2 is involved in endothelial TLR pathways along a signaling cascade that is distinct from MyD88. PMID: 21949112
    15. SDF-1 treatment of T cells induced the formation of a novel molecular signaling complex containing RasGRP1, Galphai2, and ZAP-70. PMID: 21856938
    16. Study identified a number of high-confident miR-138 target genes, including proto-oncogene GNAI2, which may play an important role in tongue squamous cell carcinoma. initiation and progression. PMID: 21079996
    17. CXCL12 upregulated T-cell activation, and an alpha(i) G-coupled protein mediated signaling pathway was necessary for stimulation of T cells by CXCL12. PMID: 12088413
    18. Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2 PMID: 12359238
    19. valproic acid-induced expression of Galphai2 is regulated by Sp1 transcription factor PMID: 12624107
    20. Cholesterol lowering by pravastatin might increase the response of the heart to parasympathetic stimulation and changes in Galpha(i2) expression might serve as a molecular marker for this effect PMID: 14623802
    21. Galphai2 has a role in calcium-sensing receptor-mediated ERK1/2 activation PMID: 14701866
    22. Abnormal regulation of GNAI2 was studied in cultured skin fibroblasts from insulin-resistant hypertensive individuals. PMID: 15126921
    23. in elderly subjects of similar ages, those with diabetes have 1.7-fold higher levels of Galpha(i2) and twofold higher levels of Gbeta(1). PMID: 15331550
    24. the Galphai2 gene promoter is transcriptionally activated through nuclear factor-kappaB and antioxidant response elements PMID: 15640523
    25. a GNAI2 -318 C>G SNP impairs transcriptional activity through specific binding of Sp1 and is associated with high SBP in Caucasians from Italy PMID: 16565233
    26. These results suggest that Galphai2 is involved specifically in the activation of TRPC4. PMID: 18854172
    27. These results show that G(i2) protein is involved in D(2)R-mediated ERK activation but beta-arrestins 1 and 2 are either not involved or play minor role. PMID: 18940181
    28. This suggests a novel set of candidate genes for NS (GNAI2 and RGS proteins) and if validated could have important implications for therapy as well. PMID: 19282110
    29. Data support the notion that oligomerization of the mu-opioid receptor is not required for agonist and antagonist binding in regard to allosteric regulation of agonist binding by Gi2. PMID: 19542234

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Membrane; Lipid-anchor. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.
  • 蛋白家族：
    G-alpha family, G(i/o/t/z) subfamily
  • 数据库链接：

    HGNC: 4385

    OMIM: 139360

    KEGG: hsa:2771

    STRING: 9606.ENSP00000312999

    UniGene: Hs.77269