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FRMD6 Antibody

  • 货号：
    CSB-PA822270ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA822270ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human duodenal tissue using CSB-PA822270ESR2HU at dilution of 1:100
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate
      All lanes: FRMD6 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 73, 71, 30 kDa
      Observed band size: 73 kDa
    • IHC image of CSB-PA822270ESR2HU diluted at 1:293 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FRMD6 Polyclonal antibody
  • Uniprot No.：
    Q96NE9
  • 基因名：
  • 别名：
    FRMD6 antibody; C14orf31FERM domain-containing protein 6 antibody; Willin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human FERM domain-containing protein 6 protein (413-622AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. a novel function of FRMD6 in inhibiting human GBM growth and progression and uncover a novel mechanism by which FRMD6 exerts its anti-GBM activity. PMID: 27661120
    2. Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease. PMID: 22190428
    3. Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway PMID: 21785462
    4. in mammalian cells willin influences Hippo signaling activity by activating the core Hippo pathway kinase cassette PMID: 21666719
    5. Results describe a new FERM domain-containing protein called Willin. PMID: 16137681

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Can colocalize with actin.
  • 数据库链接：

    HGNC: 19839

    OMIM: 614555

    KEGG: hsa:122786

    STRING: 9606.ENSP00000348550

    UniGene: Hs.434914