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  4. Recombinant Human FERM domain-containing protein 6 (FRMD6)

Recombinant Human FERM domain-containing protein 6 (FRMD6)

  • 中文名称：
    人FRMD6重组蛋白
  • 货号：
    CSB-YP822270HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FRMD6重组蛋白
  • 货号：
    CSB-EP822270HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FRMD6重组蛋白
  • 货号：
    CSB-EP822270HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FRMD6重组蛋白
  • 货号：
    CSB-BP822270HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FRMD6重组蛋白
  • 货号：
    CSB-MP822270HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    FRMD6; C14orf31FERM domain-containing protein 6; Willin
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-622
  • 氨基酸序列
    MNKLNFHNNR VMQDRRSVCI FLPNDESLNI IINVKILCHQ LLVQVCDLLR LKDCHLFGLS VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI DQFGPPMIIH FRVQYYVENG RLISDRAARY YYYWHLRKQV LHSQCVLREE AYFLLAAFAL QADLGNFKRN KHYGKYFEPE AYFPSWVVSK RGKDYILKHI PNMHKDQFAL TASEAHLKYI KEAVRLDDVA VHYYRLYKDK REIEASLTLG LTMRGIQIFQ NLDEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL IYYTGCPMRS RHLLQLLSNS HRLYMNLQPV LRHIRKLEEN EEKKQYRESY ISDNLDLDMD QLEKRSRASG SSAGSMKHKR LSRHSTASHS SSHTSGIEAD TKPRDTGPED SYSSSAIHRK LKTCSSMTSH GSSHTSGVES GGKDRLEEDL QDDEIEMLVD DPRDLEQMNE ESLEVSPDMC IYITEDMLMS RKLNGHSGLI VKEIGSSTSS SSETVVKLRG QSTDSLPQTI CRKPKTSTDR HSLSLDDIRL YQKDFLRIAG LCQDTAQSYT FGCGHELDEE GLYCNSCLAQ QCINIQDAFP VKRTSKYFSL DLTHDEVPEF VV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. a novel function of FRMD6 in inhibiting human GBM growth and progression and uncover a novel mechanism by which FRMD6 exerts its anti-GBM activity. PMID: 27661120
    2. Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease. PMID: 22190428
    3. Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway PMID: 21785462
    4. in mammalian cells willin influences Hippo signaling activity by activating the core Hippo pathway kinase cassette PMID: 21666719
    5. Results describe a new FERM domain-containing protein called Willin. PMID: 16137681

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Can colocalize with actin.
  • 数据库链接：

    HGNC: 19839

    OMIM: 614555

    KEGG: hsa:122786

    STRING: 9606.ENSP00000348550

    UniGene: Hs.434914