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FOXR2 Antibody

  • 货号：
    CSB-PA968818
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA968818(FOXR2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA968818(FOXR2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Raji cell, Primary antibody: CSB-PA968818(FOXR2 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q6PJQ5
  • 基因名：
    FOXR2
  • 别名：
    Forkhead box protein N6 antibody; Forkhead box protein R2 antibody; FOXN6 antibody; Foxr2 antibody; FOXR2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Full length fusion protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. FOXR2 might be considered as a promising therapeutic target for non-small cell lung cancer treatment. PMID: 29634928
    2. FOXR2 was up-regulated and significantly associated with poor endometrial adenocarcinoma prognosis. FOXR2 is a target gene of miR-202. PMID: 28827892
    3. FOXR2 acts with MYC to promote cancer cell proliferation, which is a potential tumor-specific target for therapeutic intervention against MYC-driven cancers. PMID: 27346356
    4. our data suggested that FOXR2 significantly promoted proliferation, invasion, and EMT of CRC cells. All these findings provided evidence for the role of FOXR2 as an oncogene in CRC development. PMID: 28548041
    5. Knockdown of FOXR2 significantly down-regulated the protein expression levels of beta-catenin. PMID: 28068638
    6. FOXR2 is frequently upregulated in hepatocellular carcinoma specimens compared with neighboring non-cancerous tissues in both messenger RNA and protein. It promoted cell growth and colony formation, and it facilitated tumor xenograft growth. beta-catenin, Skp2, c-Myc, and Gli-1 are the potential downstream effectors of FOXR2. PMID: 26846213
    7. we observed that the highly expressed FOXR2 in breast and overexpression of FOXR2 was positively associated with the progression and poor prognosis in patients with breast cancer, which indicated that FOXR2 might serve as a valuable prognosis biomarker for breast cancer individuals. PMID: 26596836
    8. Human FOXN6 gene was identified within human genome sequence RP11-167P23 ( PMID: 15202009

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in breast cancer cell lines and primary cancer.
  • 数据库链接：

    HGNC: 30469

    OMIM: 300949

    KEGG: hsa:139628

    STRING: 9606.ENSP00000427329

    UniGene: Hs.364260