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  4. Recombinant Human Forkhead box protein R2 (FOXR2)

Recombinant Human Forkhead box protein R2 (FOXR2)

  • 货号：
    CSB-YP757660HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP757660HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP757660HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP757660HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP757660HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FOXR2
  • Uniprot No.：
  • 别名：
    Forkhead box protein N6; Forkhead box protein R2; FOXN6; Foxr2; FOXR2_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-311
  • 氨基酸序列
    MDLKLKDCEF WYSLHGQVPG LLDWDMRNEL FLPCTTDQCS LAEQILAKYR VGVMKPPEMP QKRRPSPDGD GPPCEPNLWM WVDPNILCPL GSQEAPKPSG KEDLTNISPF PQPPQKDEGS NCSEDKVVES LPSSSSEQSP LQKQGIHSPS DFELTEEEAE EPDDNSLQSP EMKCYQSQKL WQINNQEKSW QRPPLNCSHL IALALRNNPH CGLSVQEIYN FTRQHFPFFW TAPDGWKSTI HYNLCFLDSF EKVPDSLKDE DNARPRSCLW KLTKEGHRRF WEETRVLAFA QRERIQECMS QPELLTSLFD L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. FOXR2 might be considered as a promising therapeutic target for non-small cell lung cancer treatment. PMID: 29634928
    2. FOXR2 was up-regulated and significantly associated with poor endometrial adenocarcinoma prognosis. FOXR2 is a target gene of miR-202. PMID: 28827892
    3. FOXR2 acts with MYC to promote cancer cell proliferation, which is a potential tumor-specific target for therapeutic intervention against MYC-driven cancers. PMID: 27346356
    4. our data suggested that FOXR2 significantly promoted proliferation, invasion, and EMT of CRC cells. All these findings provided evidence for the role of FOXR2 as an oncogene in CRC development. PMID: 28548041
    5. Knockdown of FOXR2 significantly down-regulated the protein expression levels of beta-catenin. PMID: 28068638
    6. FOXR2 is frequently upregulated in hepatocellular carcinoma specimens compared with neighboring non-cancerous tissues in both messenger RNA and protein. It promoted cell growth and colony formation, and it facilitated tumor xenograft growth. beta-catenin, Skp2, c-Myc, and Gli-1 are the potential downstream effectors of FOXR2. PMID: 26846213
    7. we observed that the highly expressed FOXR2 in breast and overexpression of FOXR2 was positively associated with the progression and poor prognosis in patients with breast cancer, which indicated that FOXR2 might serve as a valuable prognosis biomarker for breast cancer individuals. PMID: 26596836
    8. Human FOXN6 gene was identified within human genome sequence RP11-167P23 ( PMID: 15202009

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in breast cancer cell lines and primary cancer.
  • 数据库链接：

    HGNC: 30469

    OMIM: 300949

    KEGG: hsa:139628

    STRING: 9606.ENSP00000427329

    UniGene: Hs.364260