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FBXO6 Antibody

  • 货号：
    CSB-PA873634ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA873634ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA873634ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FBXO6 Polyclonal antibody
  • Uniprot No.：
    Q9NRD1
  • 基因名：
  • 别名：
    F box protein that recognizes sugar chains 2 antibody; F box G domain protein 2 antibody; F box only protein 6 antibody; F box protein 6 antibody; F box protein FBG2 antibody; F box protein Fbx6 antibody; F box/G domain protein 2 antibody; F-box only protein 6 antibody; F-box protein that recognizes sugar chains 2 antibody; F-box/G-domain protein 2 antibody; FBG 2 antibody; FBG2 antibody; FBS 2 antibody; FBS2 antibody; FBX 6 antibody; FBX6 antibody; FBX6_HUMAN antibody; FBXO 6 antibody; FBXO6 antibody; OTTHUMP00000002267 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human F-box only protein 6 protein (104-293AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
  • 基因功能参考文献：
    1. FBXO6 as a functional E3 ubiquitin ligase for Ero1L that plays a critical role in inhibiting endoplasmic reticulum stress-induced apoptosis. PMID: 27855403
    2. It might inhibit cadmium-induced ER stress by functioning as a ubiquitin ligase in the ERAD system, thereby attenuating the cell death induced by subsequent JNK1 activation. PMID: 25374377
    3. systematical identification of the FBXO6-interacting glycoproteins, critical for clarifying its substrates as well as biological functions. PMID: 22268729
    4. Two interacting proteins of human FBXO6 protein have been found using the service in the study. PMID: 22292078
    5. Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD PMID: 12939278
    6. Fbx6-dependent Chk1 degradation contributes to S phase checkpoint termination and that a defect in this mechanism might increase tumor cell resistance to certain anticancer drugs. PMID: 19716789

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  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    HGNC: 13585

    OMIM: 605647

    KEGG: hsa:26270

    STRING: 9606.ENSP00000365944

    UniGene: Hs.464419