Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human F-box only protein 6 (FBXO6)

Recombinant Human F-box only protein 6 (FBXO6)

  • 货号：
    CSB-YP873634HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP873634HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP873634HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP873634HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP873634HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    F box protein that recognizes sugar chains 2; F box G domain protein 2; F box only protein 6; F box protein 6; F box protein FBG2; F box protein Fbx6; F box/G domain protein 2; F-box only protein 6; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2; FBG 2; FBG2; FBS 2; FBS2; FBX 6; FBX6; FBX6_HUMAN; FBXO 6; FBXO6; OTTHUMP00000002267
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-293
  • 氨基酸序列
    MDAPHSKAAL DSINELPENI LLELFTHVPA RQLLLNCRLV CSLWRDLIDL MTLWKRKCLR EGFITKDWDQ PVADWKIFYF LRSLHRNLLR NPCAEEDMFA WQIDFNGGDR WKVESLPGAH GTDFPDPKVK KYFVTSYEMC LKSQLVDLVA EGYWEELLDT FRPDIVVKDW FAARADCGCT YQLKVQLASA DYFVLASFEP PPVTIQQWNN ATWTEVSYTF SDYPRGVRYI LFQHGGRDTQ YWAGWYGPRV TNSSIVVSPK MTRNQASSEA QPGQKHGQEE AAQSPYRAVV QIF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
  • 基因功能参考文献：
    1. FBXO6 as a functional E3 ubiquitin ligase for Ero1L that plays a critical role in inhibiting endoplasmic reticulum stress-induced apoptosis. PMID: 27855403
    2. It might inhibit cadmium-induced ER stress by functioning as a ubiquitin ligase in the ERAD system, thereby attenuating the cell death induced by subsequent JNK1 activation. PMID: 25374377
    3. systematical identification of the FBXO6-interacting glycoproteins, critical for clarifying its substrates as well as biological functions. PMID: 22268729
    4. Two interacting proteins of human FBXO6 protein have been found using the service in the study. PMID: 22292078
    5. Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD PMID: 12939278
    6. Fbx6-dependent Chk1 degradation contributes to S phase checkpoint termination and that a defect in this mechanism might increase tumor cell resistance to certain anticancer drugs. PMID: 19716789

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    HGNC: 13585

    OMIM: 605647

    KEGG: hsa:26270

    STRING: 9606.ENSP00000365944

    UniGene: Hs.464419