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FAM83D Antibody

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  • 货号：
    CSB-PA887979LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate, 293T whole cell lysate
      All lanes: FAM83D antibody at 4.4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 65, 63 kDa
      Observed band size: 65 kDa
    • Immunofluorescence staining of HepG2 cells with CSB-PA887979LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品描述：

    FAM83D antibody is generated from rabbits immunized with a recombinant peptide between 339-470 amino acids from the human FAM83D. Its purity is greater than 95% using protein G purified. This FAM83D antibody can be used to detect the human FAM83D protein in ELISA, WB, and IF applications.

    The FAM83D protein mainly regulates cell proliferation and differentiation. It has been shown to promote epithelial-mesenchymal transition (EMT) by activating the expression of genes that are involved in cell migration and invasion. FAM83D dysregulation has been associated with various pathological conditions, including cancer, inflammatory disorders, and developmental defects.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FAM83D Polyclonal antibody
  • Uniprot No.：
    Q9H4H8
  • 基因名：
    FAM83D
  • 别名：
    2310007D09Rik antibody; BB104611 antibody; C20orf129 antibody; CHICA antibody; dJ616B8.3 antibody; FA83D antibody; FA83D_HUMAN antibody; FAM83D antibody; Family with sequence similarity 83; member D antibody; FLJ38341 antibody; MGC92947 antibody; Protein FAM83D antibody; RGD1565583 antibody; RP23-119H5.1 antibody; Spindle protein CHICA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein FAM83D protein (339-470AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FAM83D Antibody (CSB-PA887979LA01HU)，的标记方式是Non-conjugated。对于FAM83D Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA887979LB01HU FAM83D Antibody, HRP conjugated ELISA
    FITC CSB-PA887979LC01HU FAM83D Antibody, FITC conjugated
    Biotin CSB-PA887979LD01HU FAM83D Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.
  • 基因功能参考文献：
    1. FAM83D promotes HCC recurrence by promoting CD44 expression and CD44+ CSCs malignancy. PMID: 27769048
    2. Higher level of FAM83D expression is positively correlated with an increase in genome instability in many cancer. PMID: 26678035
    3. upregulation of FAM83D, a potential oncotarget gene, may be triggered by epigenetic events and can contribute to hepatocarcinogenesis PMID: 26125229
    4. NMR-derived secondary chemical shifts and relaxation properties show that the Chica LC8 binding domain is essentially disordered with a dynamically restricted segment in one linker between motifs. PMID: 26652654
    5. Taken together, these results demonstrate that FAM83D is a novel oncogene in HCC development and may constitute a potential therapeutic target in HCC. PMID: 25646692
    6. Results demonstrate that FAM83D has prognostic value for breast cancer patients and is a novel oncogene in breast cancer development that at least in part acts through mTOR hyper-activation by inhibiting FBXW7. PMID: 24344117
    7. interaction partner of the chromokinesin Kid that is required for the generation of polar ejection forces and chromosome congression PMID: 18485706

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族：
    FAM83 family
  • 组织特异性：
    Expressed in the testis.
  • 数据库链接：

    HGNC: 16122

    KEGG: hsa:81610

    STRING: 9606.ENSP00000217429

    UniGene: Hs.726442