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  4. Recombinant Human Protein FAM83D (FAM83D)

Recombinant Human Protein FAM83D (FAM83D)

  • 中文名称：
    人FAM83D重组蛋白
  • 货号：
    CSB-YP887979HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FAM83D重组蛋白
  • 货号：
    CSB-EP887979HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FAM83D重组蛋白
  • 货号：
    CSB-EP887979HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FAM83D重组蛋白
  • 货号：
    CSB-BP887979HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FAM83D重组蛋白
  • 货号：
    CSB-MP887979HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FAM83D
  • Uniprot No.：
  • 别名：
    2310007D09Rik; BB104611; C20orf129; CHICA; dJ616B8.3; FA83D; FA83D_HUMAN; FAM83D; Family with sequence similarity 83; member D; FLJ38341; MGC92947; Protein FAM83D; RGD1565583; RP23-119H5.1; Spindle protein CHICA
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-585
  • 氨基酸序列
    MALLSEGLDE VPAACLSPCG PPNPTELFSE SRRLALEELV AGGPEAFAAF LRRERLARFL NPDEVHAILR AAERPGEEGA AAAAAAEDSF GSSHDCSSGT YFPEQSDLEP PLLELGWPAF YQGAYRGATR VETHFQPRGA GEGGPYGCKD ALRQQLRSAR EVIAVVMDVF TDIDIFRDLQ EICRKQGVAV YILLDQALLS QFLDMCMDLK VHPEQEKLMT VRTITGNIYY ARSGTKIIGK VHEKFTLIDG IRVATGSYSF TWTDGKLNSS NLVILSGQVV EHFDLEFRIL YAQSKPISPK LLSHFQSSNK FDHLTNRKPQ SKELTLGNLL RMRLARLSST PRKADLDPEM PAEGKAERKP HDCESSTVSE EDYFSSHRDE LQSRKAIDAA TQTEPGEEMP GLSVSEVGTQ TSITTACAGT QTAVITRIAS SQTTIWSRST TTQTDMDENI LFPRGTQSTE GSPVSKMSVS RSSSLKSSSS VSSQGSVASS TGSPASIRTT DFHNPGYPKY LGTPHLELYL SDSLRNLNKE RQFHFAGIRS RLNHMLAMLS RRTLFTENHL GLHSGNFSRV NLLAVRDVAL YPSYQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.
  • 基因功能参考文献：
    1. FAM83D promotes HCC recurrence by promoting CD44 expression and CD44+ CSCs malignancy. PMID: 27769048
    2. Higher level of FAM83D expression is positively correlated with an increase in genome instability in many cancer. PMID: 26678035
    3. upregulation of FAM83D, a potential oncotarget gene, may be triggered by epigenetic events and can contribute to hepatocarcinogenesis PMID: 26125229
    4. NMR-derived secondary chemical shifts and relaxation properties show that the Chica LC8 binding domain is essentially disordered with a dynamically restricted segment in one linker between motifs. PMID: 26652654
    5. Taken together, these results demonstrate that FAM83D is a novel oncogene in HCC development and may constitute a potential therapeutic target in HCC. PMID: 25646692
    6. Results demonstrate that FAM83D has prognostic value for breast cancer patients and is a novel oncogene in breast cancer development that at least in part acts through mTOR hyper-activation by inhibiting FBXW7. PMID: 24344117
    7. interaction partner of the chromokinesin Kid that is required for the generation of polar ejection forces and chromosome congression PMID: 18485706

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族：
    FAM83 family
  • 组织特异性：
    Expressed in the testis.
  • 数据库链接：

    HGNC: 16122

    KEGG: hsa:81610

    STRING: 9606.ENSP00000217429

    UniGene: Hs.726442