ETV4 Antibody

1. Experimental analysis showed the importance of LEF1, ETV4 and FABP6 as three co-regulated prognostic markers in patients with colorectal cancer metastasis. PMID: 30193961
2. Many of the ewing sarcoma family of tumors with negative NKX2.2 immunoreactivity were in bone. Strong/moderate ETV4 nuclear expression was detected in two small round cell tumors PMID: 28864350
3. FOS strongly binds to the same MED25 site as ETV4 activation domain and JUN interacts with the other two MED25 sites. PMID: 28728983
4. ETV4 overexpression is associated with lung cancer metastasis. PMID: 27869830
5. The data provide the molecular details of ETV4-mediated NANOG gene expression. PMID: 28412366
6. NCOA2ETV4 protein would contain the helixloophelix, PAS_9 and PAS_11, CITED domains, the SRC1 domain of NCOA2 and the ETS DNAbinding domain of ETV4. PMID: 27633981
7. PEA3-subgroup transcription factors are key players of the Met signaling integration involved in regulation of migration and invasiveness of tumor cells. PMID: 26238631
8. ACC1 and ACLY regulate the levels of ETV4 under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1/ACLY-alpha-ketoglutarate-ETV4 axis is a novel means by which metabolic states regulate transcriptional output PMID: 26452058
9. ETV4 overexpression is associated with prostate cancer aggressiveness. PMID: 25595908
10. molecular mechanism underlying DBC1 function in PEA3-mediated transcription involves inhibition of SIRT1 interaction with PEA3 and of SIRT1-mediated deacetylation of PEA3 PMID: 25417701
11. Implicate Pea3 as a mediator of liver metastases in colorectal cancer. PMID: 25516649
12. Silencing of ETV4 suppresses invasion of prostate cancer cells by inhibiting the expression of uPA/uPAR as well as (MMP)-2 and MMP-9 PMID: 25544710
13. data suggest that polyomavirus enhancer activator 3 and epithelium-specific transcription factor-1 may play important roles in pluri potent and tumorigenic embryonic carcinoma cells. PMID: 24694612
14. PEA3 regulates OCT4 gene expression as a transcriptional activator PMID: 24983502
15. Study reveals molecular insight into how the Ets family transcription factor Pea3 favors EMT and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2, a new Pea3 target gene. PMID: 23989931
16. Two members of the ETS (E-26) family (PEA3 and ELK-1) regulate the expression of miRNA-200b. PEA3 promotes the expression of miRNA-200b, and ELK-1 is a transcriptional repressor of miRNA-200b. PMID: 24072701
17. Review evidence for a role of ETV1, 4 and 5 as oncoproteins and describe modes of their action. PMID: 22425584
18. Notch-1 and Notch-4 are novel transcriptional targets of PEA3 in breast cancer cells. PMID: 21679465
19. These results indicated that PEA3 could activate CXCR4 promoter transcription and promote breast cancer metastasis. PMID: 21831961
20. Heterogeneous nuclear ribonucleoprotein-like protein CoAA interacts with PEA3 group member proteins and modulates their transcriptional activity. PMID: 21736557
21. High PEA3 expression is associated with gastric adenocarcinoma. PMID: 21673681
22. Study shows that the ERK-PEA3-MMP-1 axis is upregulated in oesophageal adenocarcinoma cells and is a potentially important driver of the metastatic progression of oesophageal adenocarcinomas. PMID: 21143918
23. Knockdown of MyoD and PEA3 attenuated MDR1 expression and increased the sensitivity of multidrug resistant cancer cells to cytotoxic drugs that were transported by P-gp in SGC7901/VCR cells. PMID: 20980337
24. human capicua represses mRNA expression for PEA3 (polyoma enhancer activator 3) Ets transcription factors ETV1, ETV4 and ETV5 PMID: 21087211
25. PEA3 has a central role in tumor progression in ovarian carcinoma PMID: 12684413
26. No association of E1AF levels with HER2/neu mRNA levels, hormone receptor status, histological grade, tumor size, lymph node involvement or prognosis was found. PMID: 12779089
27. role in ovarian and breast malignancies and suggests that it may be target for therapeutic intervention PMID: 15387369
28. PEA3, by its capacity to up-regulate the epithelial marker MUC4 and to down-regulate the ErbB-2 oncogene, appears as a key regulator of the differentiation/proliferation balance in pancreatic cancer cells. PMID: 15461591
29. E1AF has an essential role in the activation of the human GalT I gene in highly metastatic lung cancer cells PMID: 15611127
30. E1AF was modified by ubiquitin through the C-terminal region and ubiquitinated E1AF aggregated in nuclear dots, and the inhibition of proteasome-activated transcription from E1AF target promoters PMID: 15629152
31. important role in the early stage of colorectal carcinogenesis PMID: 15695237
32. E1AF positively regulates transcription from MT1-MMP genes, which plays an important role in invasion and metastasis of squamous cell carcinoma of the tongue by converting pro-MMP-2 into active-MMP-2 PMID: 15756447
33. results suggest E1A-F is overexpressed in early stages of human CRC development and may be an important factor in the overexpression of COX-2 and MMP-7 PMID: 15800927
34. The ETV4 protein was localised to nuclei of spermatogonia and revealed an intense staining in seminoma cells. PMID: 16158187
35. E1AF is a housekeeping gene, whose expression is controlled in specific tissues. PMID: 16297865
36. Overexpression of ETV4 is identified in 2 of 98 cases of prostate cancer. PMID: 16585160
37. These results provide evidence for the antitumor activity of PEA3 in human breast cancers. PMID: 16652376
38. These data suggest that ETV4 and Myeov may provide novel targets for therapeutic intervention. PMID: 16678123
39. By manipulating LPP levels, we show that it acts to upregulate the transactivation capacity of PEA3. PMID: 16738319
40. PEA3 expression is not correlated with HER-2/neu expression in breast cancer tumor tissues PMID: 16752078
41. PEA3 and c-Jun stimulate synergistically the HER2/neu gene transcription with p300 PMID: 16786139
42. PEA3 stabilization due to LKB1 inactivation could lead to epithelial/mesenchymal transition and greater lung cancer invasion potential. PMID: 16912160
43. Overexpression of PEA3 is associated with breast tumour progression PMID: 17060941
44. E1AF increases cell cycle progression via upregulation of Cyclin D3 transcription, which elicits a new mechanism of breast cancer growth and a new mechanism of Cyclin D3 transcription. PMID: 17467662
45. These results suggest that PEA3 is regulated by EGFR and that the elevated PEA3 expression detected in human ovarian cancer may divert cells to a more invasive phenotype by regulating MMP-9 and MMP-14. PMID: 17475671
46. Our results indicate that PIASy negatively regulates E1AF-mediated transcription by both E1AF sumoylation in a dependent and independent fashion. PMID: 17585876
47. This report describes a new mechanism of glioma invasion involving a cooperative effort between E1AF and Sp1 transcription factors. PMID: 17938207
48. E1AF plays a crucial role in the invasion and metastasis of malignant melanoma through up-regulating the MT1-MMP expression PMID: 18425363
49. The two novel ETV4 fusion partners possess as predominant common characteristics androgen-induction and prostate-specific expression. PMID: 18451133
50. E1AF overexpression markedly enhanced mithramycin A-induced Huh-7 cell apoptosis and the expression of pro-apoptotic protein Bax depending on its DNA-binding domain. PMID: 18510939

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HGNC: 3493

OMIM: 600711

KEGG: hsa:2118

STRING: 9606.ENSP00000321835

UniGene: Hs.434059