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  4. EID1 Antibody

EID1 Antibody

  • 货号：
    CSB-PA448901
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA448901(EID1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA448901(EID1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA448901(EID1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y6B2
  • 基因名：
    EID1
  • 别名：
    21 kDa pRb associated protein antibody; 21 kDa pRb-associated protein antibody; C15orf3 antibody; CBP antibody; Chromosome 15 open reading frame 3 antibody; CREBBP/EP300 inhibitor 1 antibody; CREBBP/EP300 inhibitory protein 1 antibody; CRI 1 antibody; CRI1 antibody; E1A like inhibitor of differentiation antibody; E1A-like inhibitor of differentiation 1 antibody; EID 1 antibody; EID-1 antibody; EID1 antibody; EID1_HUMAN antibody; EP300 interacting inhibitor of differentiation 1 antibody; EP300-interacting inhibitor of differentiation 1 antibody; IRO45620 antibody; MGC138883 antibody; MGC138884 antibody; NB4 apoptosis related protein antibody; PNAS 22 antibody; PNAS22 antibody; PTD014 antibody; Rb and p300 binding protein EID 1 antibody; Rb and p300 binding protein EID1 antibody; RBP21 antibody; Retinoblastoma protein associated protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human EID1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.
  • 基因功能参考文献：
    1. EID1 can modulate adipose mesenchymal stem cells, inducing a brown/beige lineage. PMID: 26643909
    2. Pcid2 is present in the CBP/p300-EID1 complex to control the switch balance of mouse and human embryonic stem cells through modulation of EID1 degradation. PMID: 24167073
    3. An unexpected EID1-binding site on SHP is located at the N terminus of the receptor, where EID1 mimics helix H1 of the nuclear receptor ligand-binding domain. PMID: 24379397
    4. This study demonstrated that overexpression of EID1 reduced hippocampal long-term potentiation and impaired spatial learning and memory function in the transgenic mice PMID: 22186421
    5. miR-138 inhibited adipogenesis through targeting the nuclear receptor coregulator EID-1 PMID: 20486779
    6. The role of EID1 in fibroblast biology and fibrosis is reported. PMID: 17559085
    7. Repression of E6 and E7 oncogenes results in restoration of pRb suppressor pathways and induced apoptosis in HPV16-positive oropharyngeal squamous cell cancer cell lines. PMID: 19276448

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and vari
  • 数据库链接：

    HGNC: 1191

    OMIM: 605894

    KEGG: hsa:23741

    STRING: 9606.ENSP00000431162

    UniGene: Hs.255973