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EID1 Antibody

  • 货号：
    CSB-PA855006
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HeLa cells, using EID1 antibody.
    • Immunofluorescence analysis of A549 cells, using EID1 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) EID1 Polyclonal antibody
  • Uniprot No.：
    Q9Y6B2
  • 基因名：
    EID1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human EID1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.
  • 基因功能参考文献：
    1. EID1 can modulate adipose mesenchymal stem cells, inducing a brown/beige lineage. PMID: 26643909
    2. Pcid2 is present in the CBP/p300-EID1 complex to control the switch balance of mouse and human embryonic stem cells through modulation of EID1 degradation. PMID: 24167073
    3. An unexpected EID1-binding site on SHP is located at the N terminus of the receptor, where EID1 mimics helix H1 of the nuclear receptor ligand-binding domain. PMID: 24379397
    4. This study demonstrated that overexpression of EID1 reduced hippocampal long-term potentiation and impaired spatial learning and memory function in the transgenic mice PMID: 22186421
    5. miR-138 inhibited adipogenesis through targeting the nuclear receptor coregulator EID-1 PMID: 20486779
    6. The role of EID1 in fibroblast biology and fibrosis is reported. PMID: 17559085
    7. Repression of E6 and E7 oncogenes results in restoration of pRb suppressor pathways and induced apoptosis in HPV16-positive oropharyngeal squamous cell cancer cell lines. PMID: 19276448

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and vari
  • 数据库链接：

    HGNC: 1191

    OMIM: 605894

    KEGG: hsa:23741

    STRING: 9606.ENSP00000431162

    UniGene: Hs.255973