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EEF1D Antibody

  • 货号：
    CSB-PA007431GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P29692
  • 基因名：
    EEF1D
  • 别名：
    Antigen NY CO 4 antibody; Antigen NY-CO-4 antibody; EEF 1D antibody; EEF1D antibody; EF 1 delta antibody; EF 1D antibody; EF-1-delta antibody; EF1D antibody; EF1D_HUMAN antibody; Elongation factor 1 delta antibody; Elongation factor 1-delta antibody; eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) antibody; Eukaryotic translation elongation factor 1 delta antibody; FP1047 antibody; Guanine nucleotide exchange protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human EEF1D
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).
  • 基因功能参考文献：
    1. eukaryotic translation elongation factor 1delta knockdown in oral squamous cell carcinoma reduced cell proliferation and induced EMT (epithelial-mesenchymal transition) phenotypes PMID: 26823560
    2. Taken together, our data suggest EFF1D functions as a novel negative regulator of SIAH-1 PMID: 21633900
    3. overexpression is positively correlated with malignant transformation of 16HBE cells induced by CdC12, but is not correlated with DNA mutations PMID: 20514991
    4. These results further confirm that overexpression of TEF-1 delta is oncogenic and the antisense TEF-1 delta mRNA expression reverses its oncogenic potential. PMID: 12210501
    5. Interaction between HrHRF and EF-1delta taken with some of the recently published information concerning the TCTP (HrHRF) mentioned above suggest a possible intracellular role for TCTP/HrHRF. PMID: 15062873
    6. Increased EF-1 delta mRNA expression is associated with lymph node metastases and advanced disease stages in esophageal carcinoma PMID: 15199388
    7. Gain of 8q-mapped EF-1 delta is associated with adverse outcome in Medulloblastoma. PMID: 16968546
    8. Repression of deltaEF1 plays a key role in mediating BMP-6-induced transcriptional activation of E-cadherin in breast cancer cells. PMID: 17997862

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  • 亚细胞定位：
    [Isoform 2]: Nucleus.
  • 蛋白家族：
    EF-1-beta/EF-1-delta family
  • 组织特异性：
    Isoform 2 is specifically expressed in brain, cerebellum and testis.
  • 数据库链接：

    HGNC: 3211

    OMIM: 130592

    KEGG: hsa:1936

    STRING: 9606.ENSP00000391944

    UniGene: Hs.333388