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DUSP15 Antibody

  • 货号：
    CSB-PA007244GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H1R2
  • 基因名：
    DUSP15
  • 别名：
    bA243J16.5 antibody; Chromosome 20 open reading frame 57 antibody; Dual specificity phosphatase 15 antibody; Dual specificity phosphatase like 15 antibody; Dual specificity protein phosphatase 15 antibody; DUS15_HUMAN antibody; DUSP15 antibody; EC 3.1.3.16 antibody; EC 3.1.3.48 antibody; FLJ20645 antibody; Vaccinia virus VH1 related dual specific protein phosphatase Y antibody; Vaccinia virus VH1-related dual-specific protein phosphatase Y antibody; VH1 related member Y antibody; VH1-related member Y antibody; VHY antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DUSP15
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6.; May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation. Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination.
  • 基因功能参考文献：
    1. The results showed that dual specificity phosphatase 15 (DUSP15) rs3746599 was significantly associated with autism under allelic, additive and dominant models,The findings initially suggest that DUSP15 might be a susceptibility gene for autism in Chinese Han population. PMID: 27223645
    2. Dusp15/VHY is a key regulator of oligodendrocyte differentiation, and PDGFR-beta and SNX6 are novel and specific Dusp15 substrates. PMID: 22792334
    3. VHY is a new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases PMID: 15138252
    4. crystal structure of catalytic domain PMID: 16170801
  • 亚细胞定位：
    Cytoplasm.; [Isoform 3]: Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 组织特异性：
    Highly expressed in testis. Expressed in brain; up-regulated in patients with multiple sclerosis gray matter lesions.
  • 数据库链接：

    HGNC: 16236

    OMIM: 616776

    KEGG: hsa:128853

    STRING: 9606.ENSP00000341658

    UniGene: Hs.434108