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  4. Recombinant Human Dual specificity protein phosphatase 15 (DUSP15)

Recombinant Human Dual specificity protein phosphatase 15 (DUSP15)

  • 中文名称：
    人DUSP15重组蛋白
  • 货号：
    CSB-YP861994HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DUSP15重组蛋白
  • 货号：
    CSB-EP861994HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DUSP15重组蛋白
  • 货号：
    CSB-EP861994HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DUSP15重组蛋白
  • 货号：
    CSB-BP861994HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DUSP15重组蛋白
  • 货号：
    CSB-MP861994HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DUSP15
  • Uniprot No.：
  • 别名：
    bA243J16.5; Chromosome 20 open reading frame 57; Dual specificity phosphatase 15; Dual specificity phosphatase like 15; Dual specificity protein phosphatase 15; DUS15_HUMAN; DUSP15; EC 3.1.3.16; EC 3.1.3.48; FLJ20645; Vaccinia virus VH1 related dual specific protein phosphatase Y; Vaccinia virus VH1-related dual-specific protein phosphatase Y; VH1 related member Y; VH1-related member Y; VHY
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-295
  • 氨基酸序列
    MTEGVLPGLY LGNFIDAKDL DQLGRNKITH IISIHESPQP LLQDITYLRI PVADTPEVPI KKHFKECINF IHCCRLNGGN CLVHCFAGIS RSTTIVTAYV MTVTGLGWRD VLEAIKATRP IANPNPGFRQ QLEEFGWASS QKGARHRTSK TSGAQCPPMT SATCLLAARV ALLSAALVRE ATGRTAQRCR LSPRAAAERL LGPPPHVAAG WSPDPKYQIC LCFGEEDPGP TQHPKEQLIM ADVQVQLRPG SSSCTLSAST ERPDGSSTPG NPDGITHLQC SCLHPKRAAS SSCTR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6.; May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation. Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination.
  • 基因功能参考文献：
    1. The results showed that dual specificity phosphatase 15 (DUSP15) rs3746599 was significantly associated with autism under allelic, additive and dominant models,The findings initially suggest that DUSP15 might be a susceptibility gene for autism in Chinese Han population. PMID: 27223645
    2. Dusp15/VHY is a key regulator of oligodendrocyte differentiation, and PDGFR-beta and SNX6 are novel and specific Dusp15 substrates. PMID: 22792334
    3. VHY is a new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases PMID: 15138252
    4. crystal structure of catalytic domain PMID: 16170801
  • 亚细胞定位：
    Cytoplasm.; [Isoform 3]: Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 组织特异性：
    Highly expressed in testis. Expressed in brain; up-regulated in patients with multiple sclerosis gray matter lesions.
  • 数据库链接：

    HGNC: 16236

    OMIM: 616776

    KEGG: hsa:128853

    STRING: 9606.ENSP00000341658

    UniGene: Hs.434108